He aha ka waikawa Shikimic?

ʻO ka waikawa Shikimic (3,4,5-trihydroxy-1-cyclohexene-1-carboxylic acid) kahi hui organik kūlohelohe i lilo i mea waena koʻikoʻi i ka biosynthesis o ka lignin, nā waikawa amino ʻala (phenylalanine, tyrosine a me tryptophan), a me ka hapa nui o nā alkaloids mea kanu a me nā microbial.

Hoʻohana pinepine ʻia ka waikawa Shikimic ma ke ʻano he mea hoʻomaka no ka hana ʻana o ka lāʻau antiviral oseltamivir (kahi lāʻau anti-H5N1 influenza virus i hoʻohana ʻia e mālama a pale i nā ʻano āpau o nā virus influenza). Ua hōʻike ʻia ka hana ʻana o (-)-zeylenone e pili ana i ka Shikimic Acid e hoʻohana nui ʻia ma ke ʻano he mea hana no ka chemotherapy maʻi kanesa. Loaʻa nā ʻikepili ma ka hana ʻana o ka monopalmitoyloxy Shikimic Acid, nona ka hana anticoagulant a hiki ke hoʻemi i ke coagulability koko ke lawelawe ʻia intramuscularly. Ua hana kahi hui noiʻi Kina i kahi derivative Shikimic Acid, triacetyl Shikimic Acid, kahi e hōʻike ana i ka hana anticoagulant a me ka antithrombotic.

Eia kekahi, ua hōʻike mai nā mea hana mai Shikimic Acid i ka hoihoi nui i ka mahiʻai ʻoiai he nui o lākou i hoʻohana ʻia e like me nā herbicides a me nā mea antimicrobial no ka mea hiki iā lākou ke ālai i ke ala Shikimic Acid i nā mea kanu a me nā bacteria me ka ʻole o ka hoʻopilikia maikaʻi ʻole i nā mammals.

No laila, hiki ke hoʻohana ʻia ka Shikimic Acid ma ke ʻano he mea hana no ka synthesis organik ma nā ʻepekema kumu a me nā noi lapaʻau i ka kemika organik a me ka lāʻau lapaʻau, ʻoi aku hoʻi no ka hoʻomākaukau ʻana i nā lāʻau like ʻole.

Ma ke ʻano he mea kemika lāʻau lapaʻau koʻikoʻi, hiki ke hoʻopili ʻia ka waikawa shikimic i ka mālama ʻana i nā maʻi he nui:

1. Antibacterial a me antitumor

I ka makahiki 1987, ua ʻike nā kānaka ʻepekema Kepanī he hopena maopopo ka hopena o ka mea hoʻopaʻa glyoxalase I i synthesized ʻia e ka methyl anthranilate ma ka laina cell Hela a me ka Escheri ascites carcinoma, hiki ke hoʻolōʻihi i ka manawa ola o nā ʻiole i hoʻopili ʻia me ka cell leukemia L1210, a he haʻahaʻa ka ʻawahia, pili nui kona hopena inhibitory i ka hopena sulfur hydride. 1988, ua hana nā kānaka ʻepekema Kina i ka makahiki 1988, ua synthesize nā kānaka ʻepekema Kina i kahi derivative acid shikimic a ua hōʻoia i ka hopena o kēia hui i ka pale ʻana i nā cell leukemia L1210 i loko o vitro.

2. Anti-thrombosis

Ua hōʻike ʻia ka hopena o ka waikawa shikimic a me kāna mau mea i loaʻa i ka ʻōnaehana cardiovascular ma ke ʻano he anti-thrombosis a me ka pale ʻana i ka hōʻiliʻili platelet. Hōʻike ka noiʻi: he hopena pale ikaika ko ka waikawa shikimic i ka nui o ka hōʻiliʻili platelet o nā ʻiole embolism artery waena i hoʻokomo ʻia e adenosine diphosphate; hiki i ka injection intravenous a me intramuscular o ka waikawa shikimic ke hoʻolōʻihi i ka manawa coagulation koko o nā ʻiole.

3. ʻO ka ischemia anti-cerebral

Loaʻa i ka waikawa Shikimic a me kāna mau mea i loaʻa ka hopena o ka hoʻomaikaʻi ʻana i ka ischemia cerebral, ʻo ia hoʻi ka hōʻemi ʻana i ka nui o ka infarction cerebral ma hope o ka ischemia cerebral focal ischemia i nā ʻiole, e hōʻemi ana i ka helu hana neurological, e hōʻemi ana i ke kiʻekiʻe o ka edema cerebral, e hoʻonui ana i ke kahe koko cerebral ma ka ʻāpana ischemic a me nā hōʻailona ʻē aʻe. Ua hōʻike kekahi mau noiʻi e hiki i kāna mau mea i loaʻa ke hōʻemi i ke kiʻekiʻe o ka hōʻuluʻulu ʻana o ka erythrocyte a kāohi i ka hōʻuluʻulu ʻana o ka platelet ma hope o ka ischemia cerebral, a pēlā e hoʻomaʻamaʻa ai i ka microcirculation cerebral.