ʻO 5-Hydroxytryptophan (5-HTP) kahi waikawa amino ʻo ia ka ʻanuʻu waena ma waena o ka tryptophan a me ka serotonin kemika lolo koʻikoʻi. Nui ka nui o nā hōʻike e hōʻike ana he hopena maʻamau ka haʻahaʻa o ka serotonin i ke ola hou. ʻO ke ʻano o ka nohona a me nā hana ʻai a ka poʻe he nui e noho nei i kēia au piha i ke kaumaha e hopena i ka haʻahaʻa o ka serotonin i loko o ka lolo. ʻO ka hopena, he nui ka poʻe i momona, makemake i ke kō a me nā kalapona ʻē aʻe, ʻike i nā manawa kaumaha, loaʻa pinepine nā poʻo poʻo, a loaʻa nā ʻehaʻeha a me nā ʻehaʻeha o nā ʻiʻo. Hiki ke hoʻoponopono ʻia kēia mau maʻi āpau ma ka hoʻokiʻekiʻe ʻana i nā pae serotonin lolo. ʻO nā noi therapeutic mua no 5-HTP he mau kūlana serotonin haʻahaʻa e like me ka mea i helu ʻia ma ka Papa 1.