Ma kahi noiʻi hou, ua ʻike nā kānaka noiʻi hiki i kahi lāʻau hou e pili ana i kahi ʻāpana o ka hua waina ke hoʻonui i ke ola a me ke olakino o nā ʻiole.
ʻO ke aʻo ʻana, i paʻi ʻia ma ka puke pai ʻo Nature Metabolism, ke kau nei i ke kahua no nā haʻawina lapaʻau hou aʻe e hoʻoholo ai inā hiki ke hana hou ʻia kēia mau hopena i loko o kānaka.
ʻO ka ʻelemakule kahi kumu pilikia nui no nā maʻi maʻi he nui. Manaʻo nā kānaka ʻepekema he hapa kēia ma muli o ka ʻelemakule ʻana o nā pūnaewele. Hana ʻia kēia i ka wā ʻaʻole hiki i nā pūnaewele ke hana hou i kā lākou mau hana olaola i loko o ke kino.
I nā makahiki i hala iho nei, ua ʻike nā kānaka noiʻi i kahi papa o nā lāʻau i kapa ʻia ʻo senolytics. Hiki i kēia mau lāʻau ke luku i nā cell senescent i nā hoʻohālike hale hana a me nā holoholona, ​​​​​​e hōʻemi ana paha i ka nui o nā maʻi maʻi e kū mai ana i ko mākou ʻelemakule a me ke ola lōʻihi.
Ma kēia noiʻi, ua ʻike nā kānaka ʻepekema i kahi senolytic hou i loaʻa mai kahi ʻāpana o ka hua waina i kapa ʻia ʻo proanthocyanidin C1 (PCC1).
Ma muli o ka ʻikepili ma mua, manaʻo ʻia ʻo PCC1 e kāohi i ka hana o nā cell senescent ma nā haʻahaʻa haʻahaʻa a luku koho i nā cell senescent ma nā kiʻekiʻe kiʻekiʻe.
Ma ka hoʻokolohua mua, ua hōʻike lākou i nā ʻiole i nā dosis sublethal o ka radiation e hoʻoulu ai i ka senescence cellular. A laila ua loaʻa i kekahi hui o nā ʻiole ʻo PCC1, a ua loaʻa i kekahi hui ke kaʻa e lawe ana iā PCC1.
Ua ʻike nā kānaka noiʻi ma hope o ka hoʻokuʻu ʻia ʻana o nā ʻiole i ka radiation, ua loaʻa iā lākou nā ʻano kino maʻamau ʻole, me ka nui o ka lauoho hina.
Ua hoʻololi nui ka mālama ʻana i nā ʻiole me PCC1 i kēia mau ʻano. ʻOi aku ka liʻiliʻi o nā pūnaewele senescent a me nā biomarkers o nā ʻiole i hāʻawi ʻia iā PCC1 e pili ana me nā pūnaewele senescent.
ʻO ka hope loa, ʻoi aku ka liʻiliʻi o ka hana a me ka ikaika o nā ʻiole i hoʻomālamalama ʻia. Eia nō naʻe, ua loli ke kūlana i nā ʻiole i hāʻawi ʻia iā PCC1, a ʻoi aku ka kiʻekiʻe o ko lākou mau helu ola.
Ma ka lua o ka hoʻokolohua, ua hoʻokomo nā kānaka noiʻi i nā ʻiole ʻelemakule me PCC1 a i ʻole kaʻa i kēlā me kēia ʻelua pule no ʻehā mahina.
Ua loaʻa i ka hui kahi nui o nā pūnaewele ʻelemakule i loko o nā puʻupaʻa, ke akepaʻa, nā māmā a me nā prostate o nā ʻiole kahiko. Eia naʻe, ua hoʻololi ka mālama ʻana me PCC1 i ke kūlana.
Ua hōʻike pū nā ʻiole i mālama ʻia me PCC1 i nā hoʻomaikaʻi ʻana i ka ikaika o ka paʻa ʻana, ka wikiwiki hele wāwae kiʻekiʻe, ke ahonui kau ʻana, ke ahonui treadmill, ka pae hana o kēlā me kēia lā, a me ke kaulike i hoʻohālikelike ʻia me nā ʻiole i loaʻa wale ke kaʻa.
Ma ke kolu o ka hoʻokolohua, ua nānā nā kānaka noiʻi i nā ʻiole kahiko loa e ʻike pehea i hoʻopilikia ai ʻo PCC1 i ko lākou ola.
Ua ʻike lākou ua ola ka ʻiole i mālama ʻia me PCC1 ma ka awelika he 9.4% ka lōʻihi ma mua o nā ʻiole i mālama ʻia me ke kaʻa.
Eia kekahi, ʻoiai ke ola lōʻihi, ʻaʻole i hōʻike nā ʻiole i mālama ʻia me PCC1 i kekahi maʻi kiʻekiʻe e pili ana i ka makahiki i hoʻohālikelike ʻia me nā ʻiole i mālama ʻia me nā kaʻa.
I ka hōʻuluʻulu ʻana i nā ʻike, ua ʻōlelo ʻo Polofesa Sun Yu mai ka Shanghai Institute of Nutrition and Health ma Kina a me nā hoa hana: "Ke hāʻawi nei mākou i ka hōʻoia o ke kumumanaʻo e hiki i ka [PCC1] ke hoʻopaneʻe nui i ka hana ʻino e pili ana i ka makahiki ʻoiai ke lawe ʻia." ma hope o ke ola, he mana nui e hōʻemi i nā maʻi e pili ana i ka makahiki a hoʻomaikaʻi i nā hopena olakino, no laila e wehe ana i nā ala hou no ka lāʻau lapaʻau geriatric e hiki mai ana e hoʻomaikaʻi i ke olakino a me ka lōʻihi o ke ola.
Ua haʻi aku ʻo Kauka James Brown, he lālā o ke Aston Center for Healthy Aging ma Birmingham, UK, iā Medical News Today ua hāʻawi nā ʻike i nā hōʻike hou aku o nā pono kūpono o nā lāʻau anti-aging. ʻAʻole i komo ʻo Kauka Brown i ka noiʻi hou.
"He papa hou nā Senolytics o nā hui anti-aging i loaʻa pinepine ʻia ma ke ʻano. Hōʻike kēia haʻawina e hiki i ka PCC1, me nā hui e like me quercetin a me fisetin, ke pepehi koho i nā cell senescent ʻoiai e ʻae ana i nā cell ʻōpio a olakino e mālama i ke ola maikaʻi."
"Ua nānā kēia haʻawina, e like me nā haʻawina ʻē aʻe ma kēia wahi, i nā hopena o kēia mau pūhui i nā rodents a me nā meaola haʻahaʻa ʻē aʻe, nui ka hana i koe ma mua o ka hoʻoholo ʻana i nā hopena anti-kahiko o kēia mau pūhui i loko o ke kanaka."
"ʻOiaʻiʻo nō ua paʻa iā Senolytics ka ʻōlelo hoʻohiki e lilo i mau lāʻau lapaʻau anti-kahiko alakaʻi i ka hoʻomohala ʻana," wahi a Kauka Brown.
Ua ʻae ʻo Polopeka Ilaria Bellantuono, ke polopeka o ka ʻelemakule musculoskeletal ma ke Kulanui o Sheffield ma UK, i loko o kahi ninaninau me MNT ʻo ka nīnau nui inā hiki ke hana hou ʻia kēia mau ʻike i loko o kānaka. ʻAʻole hoʻi i komo ʻo Polopeka Bellantuono i ke aʻo ʻana.
"Hoʻohui kēia haʻawina i ke kino o nā hōʻike e pili ana i ka hoʻopaʻa ʻana i nā cell senescent me nā lāʻau lapaʻau e pepehi koho iā lākou, i kapa ʻia ʻo 'senolytics,' hiki ke hoʻomaikaʻi i ka hana o ke kino i ko mākou wā ʻelemakule a hoʻolilo i nā lāʻau chemotherapy i ʻoi aku ka maikaʻi i ka maʻi kanesa."
"He mea nui e hoʻomaopopo ʻia ua hele mai nā ʻikepili āpau ma kēia wahi mai nā hiʻohiʻona holoholona—ma kēia hihia kūikawā, nā hiʻohiʻona ʻiole. ʻO ka pilikia maoli ka hoʻāʻo ʻana inā like ka pono o kēia mau lāʻau lapaʻau [i loko o ke kanaka]. ʻAʻohe ʻikepili i loaʻa i kēia manawa." , a ke hoʻomaka wale nei nā hoʻokolohua lapaʻau," wahi a Polofesa Bellantuono.
Ua haʻi aku ʻo Kauka David Clancy, mai ke Kulanui o Biomedicine a me Biological Sciences ma ke Kulanui ʻo Lancaster ma UK, iā MNT he pilikia paha nā pae mahele i ka wā e hoʻopili ai i nā hopena i kānaka. ʻAʻole i komo ʻo Kauka Clancy i ke aʻo hou nei.
"ʻO nā lāʻau i hāʻawi ʻia i nā ʻiole he nui loa ia i hoʻohālikelike ʻia me ka mea hiki i ke kanaka ke ʻae. ʻO nā lāʻau kūpono o PCC1 i loko o ke kanaka e hiki ke hoʻoulu i ka ʻawahia. Hiki i nā haʻawina i loko o nā ʻiole ke lilo i mea ʻike; me he mea lā ke hoʻololi nei ko lākou ake i nā lāʻau lapaʻau e like me ke ake kanaka ma mua o ke ake o ka ʻiole."
Ua haʻi aku ʻo Kauka Richard Siow, ka luna hoʻomalu o ka noiʻi ʻana i ka ʻelemakule ma King's College London, iā MNT ʻaʻole paha e alakaʻi ka noiʻi ʻana i nā holoholona ʻaʻole kanaka i nā hopena lapaʻau maikaʻi i nā kānaka. ʻAʻole hoʻi i komo ʻo Kauka Siow i ka noiʻi.
"ʻAʻole wau e hoʻohālikelike mau i ka ʻike ʻana o nā ʻiole, nā ilo a me nā nalo me nā kānaka, no ka mea, ʻo ka ʻoiaʻiʻo maʻalahi, he mau waihona panakō kā mākou a ʻaʻohe o lākou. He mau ʻeke kālā kā mākou, akā ʻaʻohe o lākou. He mau mea ʻē aʻe kā mākou i ke ola. E hoʻomaopopo i nā holoholona ʻaʻohe o mākou: ka meaʻai, ke kamaʻilio ʻana, ka hana, nā kelepona Zoom. Ke maopopo nei iaʻu hiki ke hoʻokaumaha ʻia nā ʻiole ma nā ʻano like ʻole, akā ʻoi aku ka nui o ko mākou hopohopo e pili ana i ke koena o kā mākou panakō," wahi a Kauka Xiao.
"ʻOiaʻiʻo, he mea hoʻohenehene kēia, akā no ka pōʻaiapili, ʻaʻole hiki ke unuhi ʻia nā mea āpau āu e heluhelu ai e pili ana i nā ʻiole i nā kānaka. Inā he ʻiole ʻoe a makemake ʻoe e ola a hiki i 200 mau makahiki - a i ʻole ka like o ka ʻiole. I 200 mau makahiki, he mea maikaʻi kēlā, akā he mea kūpono anei ia i nā kānaka? He mea hoʻomaopopo mau ia i ka wā e kamaʻilio ai au e pili ana i ka noiʻi holoholona."
"Ma ka ʻaoʻao maikaʻi, he haʻawina ikaika kēia e hāʻawi mai ana iā mākou i nā hōʻike ikaika e pili ana i nā ala he nui a kaʻu noiʻi ponoʻī i kālele ai he mea nui ia ke noʻonoʻo mākou i ke ola ma ke ʻano holoʻokoʻa."
"Inā he kumu hoʻohālike holoholona a he kumu hoʻohālike kanaka paha, aia paha kekahi mau ala molekala kikoʻī e pono ai mākou e nānā i loko o ka pōʻaiapili o nā hoʻokolohua lapaʻau kanaka me nā hui e like me nā proanthocyanidins hua waina," wahi a Kauka Siow.
Ua ʻōlelo ʻo Kauka Xiao ʻo kekahi mea hiki ke hana ʻia, ʻo ia ka hoʻomohala ʻana i ka ʻano hua waina ma ke ʻano he mea hoʻohui i ka meaʻai.
"ʻO ka loaʻa ʻana o kahi kumu hoʻohālike holoholona maikaʻi me nā hopena maikaʻi [a me ka paʻi ʻia ʻana ma kahi puke pai koʻikoʻi] e hoʻohui maoli i ke kaumaha i ka hoʻomohala ʻana a me ka hoʻopukapuka kālā ʻana i ka noiʻi lapaʻau kanaka, inā mai ke aupuni, nā hoʻokolohua lapaʻau a i ʻole ma o nā mea hoʻopukapuka kālā a me ka ʻoihana. E lawe i kēia papa hoʻokūkū a hoʻokomo i nā hua waina i loko o nā papa ma ke ʻano he mea hoʻohui meaʻai e pili ana i kēia mau ʻatikala."
"ʻAʻole paha i hoʻāʻo ʻia ke pākuʻi aʻu e lawe nei, akā hōʻike ka ʻikepili holoholona e hoʻonui ia i ke kaumaha - ʻo ia ka mea e alakaʻi ai i nā mea kūʻai aku e manaʻoʻiʻo aia kekahi mea i loko. He ʻāpana ia o ke ʻano o ka manaʻo o ka poʻe e pili ana i ka meaʻai." nā mea hoʻohui." ma kekahi mau ʻano, he mea pono kēia no ka hoʻomaopopo ʻana i ke ola lōʻihi," wahi a Kauka Xiao.
Ua hoʻoikaika ʻo Kauka Xiao he mea nui hoʻi ke ʻano o ke ola o ke kanaka, ʻaʻole wale ka lōʻihi o ko lākou ola ʻana.
"Inā mālama mākou i ka manaʻolana o ke ola, a ʻoi aku ka nui, ka manaʻolana o ke ola, pono mākou e wehewehe i ke ʻano o ka manaʻolana o ke ola. He mea maikaʻi inā ola mākou a hiki i 150, akā ʻaʻole maikaʻi loa inā hoʻopau mākou i nā makahiki 50 i hala ma kahi moe."
"No laila, ma kahi o ke ola lōʻihi, ʻoi aku paha ka maikaʻi o ka huaʻōlelo olakino a me ke ola lōʻihi: ke hoʻohui nei paha ʻoe i nā makahiki i kou ola, akā ke hoʻohui nei ʻoe i nā makahiki i kou ola? A i ʻole he mea ʻole kēia mau makahiki? A me ke olakino noʻonoʻo: hiki iā ʻoe ke ola a hiki i 130 mau makahiki. ʻelemakule, akā inā ʻaʻole hiki iā ʻoe ke hauʻoli i kēia mau makahiki, he mea pono anei ia?"
"He mea nui e nānā kākou i ka hiʻohiʻona ākea o ke olakino noʻonoʻo a me ka noho maikaʻi ʻana, ka nāwaliwali, nā pilikia neʻe ʻana, pehea kākou e ʻelemakule ai i loko o ke kaiāulu - ua lawa anei nā lāʻau lapaʻau? A i ʻole makemake mākou i ka mālama kaiāulu hou aku? Inā loaʻa iā mākou ke kākoʻo e ola a hiki i 90, 100 a i ʻole 110? He kulekele anei ko ke aupuni?"
"Inā ke kōkua nei kēia mau lāʻau lapaʻau iā mākou, a ua ʻoi aku ko mākou mau makahiki ma mua o 100, he aha kā mākou e hana ai e hoʻomaikaʻi i ko mākou ola ma mua o ka lawe wale ʻana i nā lāʻau lapaʻau hou aku? Eia nā hua waina, nā pomegerane, a pēlā aku," wahi a Kauka Xiao.
Ua ʻōlelo ʻo Polofesa Bellantuono he mea waiwai nui nā hopena o ke aʻo ʻana no nā hoʻokolohua lapaʻau e pili ana i nā poʻe maʻi kanesa e loaʻa ana i ka chemotherapy.
"ʻO kahi pilikia maʻamau me nā senolytics ka hoʻoholo ʻana i ka mea e pōmaikaʻi mai iā lākou a pehea e ana ai i ka pōmaikaʻi i nā hoʻokolohua lapaʻau."
"Eia kekahi, no ka mea, ʻoi aku ka maikaʻi o nā lāʻau lapaʻau he nui i ka pale ʻana i nā maʻi ma mua o ka mālama ʻana iā ia ke ʻike ʻia, hiki i nā hoʻokolohua lapaʻau ke hala i nā makahiki ma muli o nā kūlana a he pipiʻi loa ia."
"Eia nō naʻe, ma kēia hihia kūikawā, ua ʻike [nā mea noiʻi] i kahi hui o nā maʻi e pōmaikaʻi mai ia mea: nā maʻi kanesa e loaʻa ana i ka chemotherapy. Eia kekahi, ua ʻike ʻia i ka wā e hoʻoulu ʻia ai ke kūkulu ʻia ʻana o nā cell senescent (ʻo ia hoʻi e ka chemotherapy) a i ka wā "He laʻana maikaʻi kēia o kahi haʻawina hōʻoia-o-manaʻo hiki ke hana ʻia e hoʻāʻo i ka pono o nā senolytics i nā maʻi," wahi a Polofesa Bellantuono.
Ua hoʻohuli kūleʻa a palekana nā kānaka ʻepekema i nā hōʻailona o ka ʻelemakule ʻana i nā ʻiole ma o ka hoʻonohonoho hou ʻana i kekahi o kā lākou mau cell.
Ua ʻike ʻia kahi haʻawina Baylor College of Medicine ua lohi a hoʻoponopono paha nā mea hoʻohui i nā ʻano o ka ʻelemakule maoli i nā ʻiole, hiki ke hoʻolōʻihi…
Ua ʻike ʻia kahi noiʻi hou i nā ʻiole a me nā hunaola kanaka e hiki i nā hui hua ke hoʻohaʻahaʻa i ke koko. Hōʻike pū ka noiʻi i ke ʻano no ka hoʻokō ʻana i kēia pahuhopu.
Ua hoʻokomo nā kānaka ʻepekema i ke koko o nā ʻiole kahiko i loko o nā ʻiole ʻōpio e nānā i ka hopena a ʻike inā a pehea lākou i hōʻemi ai i kona mau hopena.
Ke lilo nei nā papaʻai anti-aging i mea kaulana. Ma kēia ʻatikala ke kūkākūkā nei mākou i nā ʻike o kahi loiloi hou o nā hōʻike a nīnau inā paha kekahi o…