I loko o kahi noiʻi hou, ua ʻike nā mea noiʻi ʻo kahi lāʻau lapaʻau hou i hoʻokumu ʻia ma kahi ʻāpana o ka hua waina e hiki ke hoʻolōʻihi i ke ola a me ke olakino o nā ʻiole.
ʻO ke aʻo ʻana, i paʻi ʻia ma ka puke pai Nature Metabolism, waiho i ke kumu no nā noiʻi lapaʻau hou e hoʻoholo ai inā hiki ke hana hou ʻia kēia mau hopena i nā kānaka.
ʻO ka ʻelemakule kahi kumu pilikia nui no nā maʻi maʻi maʻi. Manaʻo ka poʻe ʻepekema ʻo ia kekahi ma muli o ka ʻelemakule cellular. Hana ʻia kēia inā ʻaʻole hiki i nā cell ke hana hou i kā lākou mau hana ola i loko o ke kino.
I nā makahiki i hala iho nei, ua ʻike nā mea noiʻi i kahi papa o nā lāʻau i kapa ʻia he senolytics. Hiki i kēia mau lāʻau lapaʻau ke hoʻopau i nā cell senescent i loko o ke keʻena hoʻohālike a me nā ʻano holoholona, ​​​​hiki ke hōʻemi i ka ulu ʻana o nā maʻi maʻi e kū mai ana i ko mākou mau makahiki a ola lōʻihi.
I loko o kēia haʻawina, ua ʻike nā kānaka ʻepekema i kahi senolytic hou i loaʻa mai kahi ʻāpana o ka hua waina i kapa ʻia ʻo proanthocyanidin C1 (PCC1).
Ma muli o ka ʻikepili mua, manaʻo ʻia ʻo PCC1 e kāohi i ka hana o nā cell senescent ma nā haʻahaʻa haʻahaʻa a koho i ka luku ʻana i nā cell senescent ma nā kiʻekiʻe kiʻekiʻe.
I ka hoʻokolohua mua, ua hōʻike lākou i nā ʻiole i ka sublethal doses o ka radiation e hoʻoulu ai i ka senescence cellular. Ua loaʻa i kekahi pūʻulu ʻiole ka PCC1, a ua loaʻa i ka hui ʻē aʻe ka kaʻa lawe PCC1.
Ua ʻike nā mea noiʻi ma hope o ka ʻike ʻia ʻana o nā ʻiole i ka radiation, ua hoʻomohala lākou i nā ʻano kino kino ʻole, me ka nui o ka lauoho hina.
ʻO ka mālama ʻana i nā ʻiole me PCC1 i hoʻololi nui i kēia mau ʻano. ʻO nā ʻiole i hāʻawi ʻia i ka PCC1 he liʻiliʻi nā pūnaewele senescent a me nā biomarkers pili me nā cell senescent.
ʻO ka mea hope loa, ua emi ka hana a me ka ikaika o ka ʻiʻo o nā ʻiole i hoʻohuhi ʻia. Eia nō naʻe, ua loli ke kūlana i nā ʻiole i hāʻawi ʻia iā PCC1, a ua ʻoi aku ka nui o ke ola.
I ka lua o ka hoʻokolohua, ua hoʻokomo nā mea noiʻi i nā ʻiole kahiko me PCC1 a i ʻole kaʻa i kēlā me kēia pule ʻelua no ʻehā mahina.
Ua loaʻa i ka hui ka nui o nā pūnaewele senescent i loko o nā puʻupaʻa, ate, akemāmā a me nā prostate o nā ʻiole kahiko. Eia naʻe, ua hoʻololi ka mālama ʻana me PCC1 i ke kūlana.
Ua hōʻike pū ʻia nā ʻiole i mālama ʻia me PCC1 i ka hoʻomaikaʻi ʻana i ka ikaika o ka puʻupuʻu, ka wikiwiki o ka hele wāwae, ke kau ʻana i ka hoʻomanawanui, ka hoʻomanawanui ʻana o ka treadmill, ka pae hana o kēlā me kēia lā, a me ke kaulike i hoʻohālikelike ʻia me nā ʻiole i loaʻa ka kaʻa wale nō.
Ma ke kolu o ka hoʻokolohua, ua nānā nā mea noiʻi i nāʻiole kahiko loa eʻike i ka hopena o ka PCC1 i ko lākou ola.
Ua ʻike lākou ua ola nā ʻiole i mālama ʻia me PCC1 i ka awelika o 9.4% lōʻihi ma mua o nā ʻiole i mālama ʻia me ka kaʻa.
Eia kekahi, ʻoiai ka lōʻihi o ka noho ʻana, ʻaʻole i hōʻike ʻia nā ʻiole i mālama ʻia e PCC1 i kahi maʻi maʻi kiʻekiʻe e pili ana i ka makahiki i hoʻohālikelike ʻia me nā ʻiole i mālama ʻia i ka kaʻa.
I ka hōʻuluʻulu ʻana i nā ʻike, ua ʻōlelo ka mea kākau ʻōlelo ʻo Professor Sun Yu mai ka Shanghai Institute of Nutrition and Health ma Kina a me nā hoa hana: "Ke hāʻawi nei mākou i ka hōʻoia o ka manaʻo o [PCC1] ka hiki ke hoʻopaneʻe nui i ka dysfunction pili i ka makahiki ʻoiai ke lawe ʻia." ma hope o ke ola, hiki ke hōʻemi i nā maʻi pili makahiki a hoʻomaikaʻi i nā hopena olakino, a laila e wehe ana i nā ala hou no ka lāʻau lapaʻau geriatric e hiki mai ana e hoʻomaikaʻi i ke olakino a me ka lōʻihi.
Ua haʻi aku ʻo Dr James Brown, he lālā o ka Aston Center for Healthy Aging ma Birmingham, UK, i ka Medical News Today e hāʻawi nā ʻike i nā hōʻike hou aʻe o nā pono kūpono o nā lāʻau anti-aging. ʻAʻole i komo ʻo Kauka Brown i ka noiʻi hou.
"ʻO Senolytics kahi papa hou o nā pūhui anti-aging i loaʻa maʻamau i ke ʻano. Hōʻike kēia haʻawina i ka PCC1, me nā pūhui e like me ka quercetin a me ka fisetin, hiki ke koho i ka pepehi ʻana i nā cell senescent oiai e ʻae ana i nā ʻōpio, nā pūnaewele olakino e mālama i ka ola maikaʻi. ”
"ʻO kēia haʻawina, e like me nā haʻawina ʻē aʻe ma kēia wahi, ua nānā i nā hopena o kēia mau pūhui i nā rodents a me nā mea ʻē aʻe haʻahaʻa, no laila nui ka hana ma mua o ka hiki ke hoʻoholo ʻia nā hopena anti-aging o kēia mau pūhui i loko o ke kanaka."
"ʻOiaʻiʻo ka paʻa ʻana o nā Senolytics i ka ʻōlelo hoʻohiki o ke alakaʻi ʻana i nā lāʻau anti-kahiko i ka hoʻomohala ʻana," wahi a Kauka Brown.
Ua ʻae ʻo Polofesa Ilaria Bellantuono, ke kaukaʻi o ka ʻelemakule musculoskeletal ma ke Kulanui o Sheffield ma UK, i ka hālāwai ninaninau me MNT ʻo ka nīnau nui inā hiki ke hoʻopili hou ʻia kēia mau ʻike i nā kānaka. ʻAʻole i komo ʻo Polofesa Bellantuono i ke aʻo ʻana.
"Hoʻohui kēia haʻawina i ke kino o nā hōʻike e ʻimi ana i nā cell senescent me nā lāʻau lapaʻau e pepehi koho iā lākou, i kapa ʻia ʻo 'senolytics,' hiki ke hoʻomaikaʻi i ka hana kino i ko mākou mau makahiki a hoʻomaikaʻi i nā lāʻau lapaʻau chemotherapy i ka maʻi kanesa."
“He mea nui e hoʻomaopopo i nā ʻikepili āpau ma kēia wahi mai nā hiʻohiʻona holoholona—i kēia hihia, nā hiʻohiʻona ʻiole. ʻO ka paʻakikī maoli ʻo ka hoʻāʻo ʻana inā like kēia mau lāʻau lapaʻau [i nā kānaka]. ʻAʻohe ʻikepili i loaʻa i kēia manawa. " , a ke hoʻomaka nei nā hoʻokolohua lapaʻau," wahi a Profesor Bellantuono.
Ua haʻi aku ʻo Dr David Clancy, mai ka Faculty of Biomedicine and Biological Science ma Lancaster University ma UK, i ka MNT e hiki ke hoʻopiʻi nā pae maʻi i ka wā e hoʻopili ai i nā hopena i nā kānaka. ʻAʻole i komo ʻo Kauka Clancy i ka noiʻi hou.
"ʻO ka nui o nā ʻiole i hāʻawi ʻia i nā ʻiole i hoʻohālikelike ʻia i ka mea e hiki ai i ke kanaka ke ʻae. Hiki ke hoʻopōʻino ke kumu o ka PCC1 i ke kanaka. Hiki ke ʻike i nā haʻawina i nā ʻiole; ʻIke ʻia ko lākou ate e hoʻomake i nā lāʻau lapaʻau e like me ke ake o ke kanaka ma mua o ka ate ʻiole. ”
Ua haʻi pū ʻo Dr Richard Siow, ka luna o ka noiʻi ʻelemakule ma King's College London, i ka MNT ʻaʻole hiki i ka noiʻi holoholona kanaka ʻole ke alakaʻi i nā hopena lapaʻau maikaʻi i nā kānaka. ʻAʻole hoʻi i komo ʻo Kauka Siow i ka haʻawina.
“ʻAʻole au e hoʻohālikelike mau i ka loaʻa ʻana o nā ʻiole, nā ilo a me nā nalo me nā kānaka, no ka mea, ʻo ka ʻoiaʻiʻo maʻalahi he mau waihona waihona kā mākou a ʻaʻole lākou. Loaʻa iā mākou nā ʻeke kālā, akā ʻaʻole lākou. Loaʻa iā mākou nā mea ʻē aʻe i ke ola. Hoʻomaopopo i nā holoholona ʻAʻole mākou: meaʻai, kamaʻilio, hana, kelepona Zoom. Manaʻo wau hiki ke koʻikoʻi i nā ʻiole ma nā ʻano like ʻole, akā maʻamau, ʻoi aku ka hopohopo no kā mākou koena panakō, "wahi a Kauka Xiao.
"ʻOiaʻiʻo, he ʻakaʻaka kēia, akā no ka pōʻaiapili, ʻaʻole hiki ke unuhi ʻia nā mea a pau āu e heluhelu ai e pili ana i nā ʻiole i ke kanaka. Inā he ʻiole ʻoe a makemake ʻoe e ola i 200 mau makahiki - a i ʻole ka ʻiole like. I ka makahiki 200, he mea maikaʻi loa ia, akā, kūpono anei ia i nā kānaka? He ʻōlelo hoʻopaʻa kēlā ke kamaʻilio wau e pili ana i ka noiʻi holoholona.
"Ma ka ʻaoʻao maikaʻi, he haʻawina ikaika kēia e hāʻawi iā mākou i nā hōʻike ikaika ʻoiai ʻo ka nui o nā alahele aʻu i nānā pono ai he mea nui i ka wā e noʻonoʻo ai mākou e pili ana i ke ola ma ka laulā."
"Inā he ʻano holoholona a i ʻole ke ʻano kanaka, aia kekahi mau ala molekala kikoʻī e pono ai mākou e nānā i ke ʻano o nā hoʻokolohua lapaʻau kanaka me nā pūhui e like me ka hua waina proanthocyanidins," wahi a Kauka Siow.
Ua ʻōlelo ʻo Kauka Xiao, ʻo ka hoʻomohala ʻana i ka hua waina ma ke ʻano he meaʻai.
"ʻO ka loaʻa ʻana o kahi hiʻohiʻona holoholona maikaʻi me nā hopena maikaʻi [a me ka paʻi ʻana i kahi puke moʻolelo kiʻekiʻe] e hoʻohui maoli i ke kaumaha i ka hoʻomohala ʻana a me ka hoʻopukapuka ʻana i ka noiʻi lapaʻau kanaka, inā mai ke aupuni, nā hoʻokolohua lapaʻau a i ʻole ma o nā mea hoʻopukapuka a me nā ʻoihana. Lawe i kēia papa hoʻokūkū a hoʻokomo i nā hua waina i loko o nā papa ma ke ʻano he meaʻai meaʻai e pili ana i kēia mau ʻatikala.
"ʻAʻole paha i hoʻāʻo ʻia ka mea hoʻohui aʻu e lawe nei, akā hōʻike ka ʻikepili holoholona i ka hoʻonui ʻana i ke kaumaha - e alakaʻi ana i nā mea kūʻai aku e manaʻoʻiʻo aia kekahi mea i loko. He ʻāpana ia o ka manaʻo o ka poʻe e pili ana i ka meaʻai. mea hoʻohui. i kekahi mau ʻano, pono kēia no ka hoʻomaopopo ʻana i ka lōʻihi o ke ola, "wahi a Dr. Xiao.
Ua ʻōlelo ʻo Kauka Xiao he mea nui ka maikaʻi o ke ola o ke kanaka, ʻaʻole wale ka lōʻihi o kona ola ʻana.
"Inā mālama mākou i ka manaʻolana o ke ola a, ʻoi aku ka mea nui, ka manaʻolana o ke ola, pono mākou e wehewehe i ke ʻano o ke ola. ʻAʻole maikaʻi inā ola mākou i 150, akā ʻaʻole maikaʻi loa inā mākou e noho i nā makahiki he 50 i hala ma kahi moe.
"No laila ma kahi o ka lōʻihi, ʻoi aku ka maikaʻi o ke olakino a me ke ola lōʻihi: hiki paha iā ʻoe ke hoʻohui i nā makahiki i kou ola, akā ke hoʻohui nei ʻoe i nā makahiki i kou ola? He mea ole paha keia mau makahiki? A me ke olakino noʻonoʻo: hiki iā ʻoe ke ola a hiki i 130 mau makahiki. kahiko, akā inā ʻaʻole hiki iā ʻoe ke hauʻoli i kēia mau makahiki, pono anei ia?"
“He mea koʻikoʻi ke nānā aku i ka ʻike ākea o ke olakino noʻonoʻo a me ka maikaʻi, nāwaliwali, nā pilikia o ka neʻe ʻana, pehea ko mākou mau makahiki i ke kaiāulu - lawa anei nā lāʻau lapaʻau? A i ʻole pono mākou i ka mālama kaiaulu? Inā loaʻa iā mākou ke kākoʻo e ola i 90 , 100 a i ʻole 110? He kulekele anei ke aupuni?”
"Inā kōkua kēia mau lāʻau iā mākou, a ʻoi aku mākou ma mua o 100 mau makahiki, he aha kā mākou e hana ai e hoʻomaikaʻi ai i ko mākou ola ma mua o ka lawe ʻana i nā lāʻau hou aku? Eia na hua waina, pomegerane, a pela aku," wahi a Kauka Xiao. .
Ua ʻōlelo ʻo Polofesa Bellantuono he mea waiwai nui nā hopena o ka noiʻi no nā hoʻokolohua lapaʻau e pili ana i nā maʻi maʻi maʻi e loaʻa ana i ka chemotherapy.
"ʻO kahi paʻakikī maʻamau me nā senolytics ka hoʻoholo ʻana i ka mea e pōmaikaʻi mai iā lākou a pehea e ana i ka pōmaikaʻi i nā hoʻokolohua lapaʻau."
"Eia kekahi, no ka mea ʻoi aku ka maikaʻi o nā lāʻau lapaʻau i ka pale ʻana i nā maʻi ma mua o ka mālama ʻana i ka wā i ʻike ʻia ai, hiki i nā hoʻokolohua lapaʻau ke lawe i nā makahiki ma muli o nā kūlana a e pāpā ʻia ke kumukūʻai."
"Akā naʻe, i kēia hihia, ua ʻike [nā mea noiʻi] i kahi hui o nā maʻi e pōmaikaʻi mai ia: nā maʻi maʻi maʻi e loaʻa ana i ka chemotherapy. Eia kekahi, ua ʻike ʻia i ka wā e hoʻokumu ʻia ai nā cell senescent (ʻo ia hoʻi e ka chemotherapy) a i ka wā "He kumu hoʻohālike maikaʻi kēia o kahi haʻawina hōʻoia-o-manaʻo hiki ke hana ʻia e hoʻāʻo ai i ka maikaʻi o nā senolytics i nā maʻi," wahi a Polofesa. Bellantuono. ”
Ua holomua a palekana ka poʻe ʻepekema i nā hōʻailona o ka ʻelemakule o nā ʻiole ma o ka hoʻoponopono hou ʻana i kekahi o kā lākou mau cell.
Ua ʻike ʻia kahi noiʻi ʻo Baylor College of Medicine e hoʻolōʻihi a hoʻoponopono paha nā mea hoʻohui i nā ʻano o ka ʻelemakule kūlohelohe i nā ʻiole, hiki ke hoʻolōʻihi i ka ...
Ua ʻike ʻia kahi noiʻi hou i nā ʻiole a me nā pūnaewele kanaka e hiki ke hoʻohaʻahaʻa i ke kahe koko. Hōʻike pū ka haʻawina i ke ʻano o ka hoʻokō ʻana i kēia pahuhopu.
Ua hoʻokomo ka poʻe ʻepekema i ke koko o nā ʻiole kahiko i nā ʻiole ʻōpio e nānā i ka hopena a ʻike inā a pehea lākou e hoʻēmi ai i kona hopena.
Ke ulu nui nei nā meaʻai anti-ʻelemakule. Ma kēia ʻatikala e kūkākūkā mākou i nā ʻike o kahi loiloi hou o nā hōʻike a nīnau inā paha kekahi o…