1. Nā mea kū'ē i ka Endothelin

Lawe ʻia ia mai ka chamomile herb ʻEulopa, hiki ke pale i ka endothelin a pale i ka hana ʻana o nā melanocytes. ʻO ka māhele like ʻole o ka endothelin i ka ʻili ke kumu nui e alakaʻi ai i ka hoʻokumu ʻana o ka pigmentation. Hiki i ka Endothelin antagonists ke kāohi i ka endothelin.. tyrosinase a hoʻoikaika i ka ʻokoʻa o nā melanocytes.

Ua ʻike nā haʻawina he haʻahaʻa ka cytotoxicity o ka endothelin antagonists i unuhi ʻia mai nā meaola wai a hiki ke kāohi i ka ʻokoʻa o ka endothelin ma nā melanocytes a me ka hana o tyrosinase. ʻO nā maʻi hyperpigmentation o ka ʻili ma muli o ka hoʻonui -l hiki ke loaʻa nā manaʻo noi.

2. ʻO Resveratrol a me kāna mau mea i loaʻa

ResveratrolAia ka nui i loko o nā hua waina, Polygonum cuspidatum, Veratrum a me nā mea kanu ʻē aʻe, a ke kāohi nei i ka hana o nā melanocytes a me ka hana o tyrosinase i ke ʻano hilinaʻi, e hōʻemi ana i ka synthesis melanin. Ua ʻike ʻo Jeong et al ua pili pū me nā protein pili tyrosinase i ka melanogenesis.

Ua hōʻike ʻo Jia Lili a me nā haʻawina ʻē aʻe e hiki i ka resveratrol topical ke hoʻomaikaʻi maikaʻi i ka waihoʻoluʻu ʻili, loaʻa kahi hopena keʻokeʻo, a ʻaʻohe hopena ʻino. Loaʻa ka Resveratrol i nā hemahema o ka instability a me ka bioavailability maikaʻi ʻole. Ua ʻike nā haʻawina ʻo kāna mau derivatives (pentaalkyl ether derivatives a me tetraester derivatives) he bioavailability kiʻekiʻe a hiki ke kāohi maikaʻi i ka synthesis o melanin. Loaʻa iā ia nā manaʻo noi ākea i nā mea hoʻonaninani keʻokeʻo.

3. Kamelika Extract

ʻO Camellia ka ʻohana Camellia o ka ʻohana Camellia. Nakamura et al. Ua ʻike ʻia ʻo ka ʻōpala pua camellia hiki ke kāohi i ka hana melanin a hoʻoikaika i ka ʻokoʻa fibroblast. Ua hoʻoholo ʻo Huang Xiaofeng a me nā haʻawina ʻē aʻe he ʻoi aku ka maikaʻi o ka lālā kī a Dianshan ma mua o arbutin ma ke ʻano o ka hoʻonui ʻana o ke kelepona a me ka hoʻopaʻa ʻana i ka hana tyrosinase, a ʻoi aku ka maikaʻi o nā waiwai ma mua o arbutin. He ʻano hou ia o ka ʻili keʻokeʻo keʻokeʻo a loaʻa i kahi ākea o nā noi. manaʻolana.

MelaninSynthaseImea hōʻole

1. Arbutin

He mea koʻikoʻi ia o ka tyrosinase inhibitor, hiki ke pale i ka hana o tyrosinase, ālai i ka synthesis o dopa a me dopaquinone, a laila e pale ai i ka hana ʻana o ka melanin, a hiki ke hoʻemi nui i ka pigmentation i hana ʻia e nā kukui ultraviolet, akā paʻa ka hana maikaʻi ʻole, me kekahi. kiʻi kiʻi.

Ua ʻike ʻia ka haʻawina ʻo ka arbutin me ka hoʻopaʻa ʻana o 3% he mau waiwai maikaʻi, haʻahaʻa cytotoxicity, irritation a me ka allergy, a ʻo ka palena kiʻekiʻe o kona ʻike ʻaʻole hiki ke ʻoi aku ma mua o 7%. ʻO kahi kiʻekiʻe o ka arbutin e decolorize i ka ʻili maʻamau. ʻO kāna mea hana maoli, ʻo glucopyranoside, ʻoi aku ka ikaika o ka pale ʻana i ka tyrosinase kanaka ma mua o ka arbutin, a pani i ka arbutin no ka mea ʻoi aku ka maikaʻi a paʻa.

2. Laki Laki

ʻO kāna mau mea hana he liquiritin, isoliquiritin a me nā flavonoids licorice. Hana ʻo Liquiritin i ka melanin o ka ʻili ma ka hoʻopuehu ʻana i ka melanin aggregated, a loaʻa ka hopena keʻokeʻo; ʻO ka hana nui o nā flavonoids licorice ke kāohi i ka hana o tyrosinase, DHICA oxidase a me dopa pigment intermutase.

Ua ʻike nā haʻawina ʻo nā huahana mālama ʻili lapaʻau i loaʻa i ka licorice extract a me ka papain hiki ke kōkua i ka melasma a me ka hyperpigmentation post-inflammatory, me ka liʻiliʻi o nā hopena ʻino, a loaʻa kekahi .. a me .. waiwai. ʻO kona koʻikoʻi i nā huahana keʻokeʻo he 10% a 40%, akā ʻaʻole kiʻekiʻe ka ʻike o nā mea hana i ka licorice a paʻakikī a paʻakikī ka hoʻomaʻemaʻe.

3. ʻO Chuanxiong Extract

Ua ʻike nā haʻawina ʻo Chuanxiong extract hiki ke kāohi pono i ka hana o tyrosinase, e hōʻike ana i kahi hopena inhibitory hoʻokūkū. Ua hoʻomohala ʻia ka ʻaila ʻo Chuanqiong ma o ka hui pū ʻana o nā emulsifiers like ʻole a me nā mānoanoa like ʻole, ua hōʻike ka noiʻi e pili ana i kona pono keʻokeʻo a me ka hana ʻana i ka 0.5% ~ 1.0% ʻo Chuanqiong hinu i nā hiʻohiʻona o ke kūpaʻa maikaʻi, ka hana kiʻekiʻe a me ka hopena keʻokeʻo maikaʻi.

4. ʻO Rhodiola Rosea Extract

ʻO Salidroside a me flavonoids kāna mau mea hana nui, a hiki i ka salidroside ke hōʻino i nā lipids a me nā membrane cell e nā kukuna ultraviolet. Hiki i ka extract ke kāohi i ka synthesis o ka melanin a me ka hana o tyrosinase, a he mea hoʻomaʻemaʻe ʻili maikaʻi. Ua ʻike ʻia ka haʻawina ʻo 1% a me 5% o Rhodiola rosea extract ʻaʻole i hana i nā hopena ʻino i ke kino o ke kanaka, a he mea hana hoʻonaninani me ka paʻa kiʻekiʻe a he ʻoi aku ka manaʻo ākea i nā noi hoʻonaninani.

5. Aloina

He glycoprotein mea kanu kaumaha haʻahaʻa i lawe ʻia mai ka aloe vera. Hoʻopaʻa nui ia i ka hoʻokumu ʻana o dopaquinone ma ka hoʻokūkū hoʻokūkū i ka dopa oxidation site, a hoʻokō i ka hoʻokūkū hoʻokūkū ʻole ma ka hoʻokūkū hoʻokūkū i nā ion keleawe ma ka pūnaewele hydroxylase. ʻO ka hana o tyrosine hydroxylase. Eia kekahi, hiki i ka aloin ke hoʻemi i ka ʻeleʻele o ka ʻili ma muli o nā kukuna ultraviolet, a he hopena hoʻoponopono maikaʻi i ka ʻili ma hope o ka ʻike ʻana o ka lā. ʻO ka aloin he hydrophilic a non-cytotoxic. Hiki i ka hui ʻana i ka aloin me ka arbutin ke hoʻomaikaʻi i ka hopena keʻokeʻo.

6. Mea kanu Polyphenols

Loaʻa ia i ka ʻili, nā aʻa, nā lau a me nā hua o nā mea kanu, a ʻo kona hopena keʻokeʻo e pili nui ana i kona absorption o nā kukui ultraviolet, antioxidant elimination o nā radical manuahi, a me ka inhibition o tyrosinase a me nā hana peroxidase. ʻO ka waika Ellagic he polyphenol maoli i unuhi ʻia mai ka ʻili pomegerane, ka ʻili a me nā huaʻai a me nā mea kanu like ʻole. Hiki iā ia ke pale i ka hoʻonui ʻana o nā melanocytes, ke kāohi i ka hana o ka melanocyte tyrosinase, e hoʻemi i ka synthesis melanin, ʻo nā kukui Ultraviolet he hopena absorption ikaika, hiki ke pāʻani i ka pale ʻana i ka lā a i ʻole ka scavenging free radical ma o ka lawe ʻana i nā kukuna ultraviolet. ʻO ka mea kanu polyphenol kahi ʻano mea hana pono, nona nā manaʻo ākea no ka hoʻomohala ʻana a me ka hoʻohana ʻana i nā mea hoʻonaninani.

Nā kikoʻī pili:
Shaanxi Ruiwo Phytochem Co.,Ltd.
Luna Hoʻokele o nā ʻāina ʻē: Jason
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leka uila:jason@ruiwophytochem.com
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