Ma waena o nā pepa hou loa e pili ana i kēia antioxidant ikaika he loiloi i paʻi ʻia ma Phytotherapy Research i Malaki 2019, nāna i loiloi i 9 mau mea e pili ana i nā hopena o ka quercetin ma ka metabolic syndrome.

ʻO ka metabolic syndrome e pili ana i kahi ʻano o nā pilikia olakino e hoʻonui ai i ka pilikia o ka maʻi diabetes type 2, ka maʻi puʻuwai, a me ka hahau, me ke koko kiʻekiʻe, ke kō koko kiʻekiʻe, nā pae triglyceride kiʻekiʻe, a me ka hōʻiliʻili ʻana o ka momona o ka pūhaka.

ʻOiai ua ʻike ʻia nā haʻawina piha ʻaʻohe hopena o ka quercetin i ka glucose koko hoʻokē ʻai, ke kūʻē ʻana o ka insulin a i ʻole nā ​​​​pae hemoglobin A1c, ua hōʻike hou ka loiloi subgroup ua hoʻohui ʻia ka quercetin i nā haʻawina i lawe ma ka liʻiliʻi he 500 mg i kēlā me kēia lā no ka liʻiliʻi he ʻewalu pule. " Ua hoʻemi nui ʻia ke kō koko hoʻokē ʻai.

Kōkua ʻo Quercetin i ka hoʻoponopono ʻana i ka hōʻike ʻana o nā genes

Wahi a kahi noiʻi i paʻi ʻia ma 2016, hiki i ka quercetin ke hoʻoulu i ke kahawai mitochondrial o apoptosis (ka make ʻana o nā cell i hoʻopau ʻia) ma ka launa pū ʻana me ka DNA, a laila e hoʻoulu ai i ka regression tumor.

Ua ʻike ʻia nā haʻawina hiki i ka quercetin ke hoʻoulu i ka cytotoxicity o nā cell leukemia, a pili ka hopena i ka nui. Ua ʻike ʻia hoʻi nā hopena cytotoxic palena ʻia i loko o nā cell maʻi umauma. Ma ke ʻano laulā, hiki i ka quercetin ke hoʻolōʻihi i ke ola o nā ʻiole maʻi ma 5 mau manawa i hoʻohālikelike ʻia me ka hui kaohi i mālama ʻole ʻia.

Ua hāʻawi nā mea kākau i kēia mau hopena i ka pilina pololei ma waena o ka quercetin a me ka DNA a me kona hoʻāla ʻana i ke ala mitochondrial o ka apoptosis, a hōʻike lākou he mea kūpono ka hoʻohana ʻana i ka quercetin ma ke ʻano he lāʻau adjuvant no ka mālama ʻana i ka maʻi kanesa.

Ua hoʻoikaika pū kekahi noiʻi hou i paʻi ʻia ma ka puke pai Molecules i nā hopena epigenetic o quercetin a me kona hiki ke:

Ka launa pū ʻana me nā kahawai hōʻailona kelepona
Hoʻoponopono i ka hōʻike ʻana o ka gene
Hoʻopilikia i ka hana o nā kumu hoʻololi
Hoʻoponopono i ka waikawa microribonucleic (microRNA)

Ua manaʻo ʻia ka waikawa microribonucleic he DNA "ʻōpala". Ua ʻike ʻia nā noiʻi ʻaʻole ia he mea ʻole ka DNA "ʻōpala". He mole liʻiliʻi ia o ka waikawa ribonucleic, nona ke kuleana koʻikoʻi i ka hoʻoponopono ʻana i nā genes e hana ana i nā protein kanaka.

Hiki ke hoʻohana ʻia ka waikawa Microribonucleic ma ke ʻano he "kuhi" o kēia mau genes. Wahi a ka hoʻokomo ʻana o ka waikawa microribonucleic, hiki i kahi gene ke hoʻopili i kekahi o nā huahana protein he 200 a ʻoi aku. ʻO ka hiki o Quercetin ke hoʻololi i nā microRNAs e wehewehe pū i kona hopena cytotoxic a no ke aha e hoʻonui ai i ke ola ʻana o ka maʻi kanesa (ma ka liʻiliʻi no nā ʻiole).

He mea hoʻohui antiviral ikaika ʻo Quercetin

E like me ka mea i ʻōlelo ʻia ma luna, ʻo ka noiʻi i hana ʻia e pili ana i ka quercetin e kālele ana i kona hiki ke antiviral, ʻo ia hoʻi ma muli o ʻekolu mau ʻano hana:

Kāohi i ka hiki o nā virus ke hoʻopili i nā cell
Kāohi i ka hana hou ʻana o nā pūnaewele i loaʻa i ka maʻi
E hōʻemi i ke kū'ē'ē o nā pūnaewele i loa'a i ka ma'i i ka lā'au lapa'au antiviral

No ka laʻana, ua ʻike ʻia kahi noiʻi i kālā ʻia e ka US Department of Defense i paʻi ʻia ma 2007 ma hope o ka loaʻa ʻana o ke kaumaha kino koʻikoʻi, hiki i ka quercetin ke hōʻemi i kou pilikia o ka loaʻa ʻana o ka maʻi a hoʻomaikaʻi i kāu hana noʻonoʻo, inā ʻaʻole hiki ke hōʻino i kāu hana pale, e hoʻolilo iā ʻoe i mea maʻalahi i nā maʻi.

Ma kēia noiʻi, ua loaʻa i nā mea holo paikikala he 1000 mg o ka quercetin i ka lā, i hui pū ʻia me ka huaora C (e hoʻonui ana i nā pae quercetin plasma) a me ka niacin (e paipai ana i ka omo ʻana) no ʻelima mau pule i ka lālani. Ua ʻike ʻia nā hopena i hoʻohālikelike ʻia me ka mea i mālama ʻole ʻia No kekahi mea holo paikikala i mālama ʻia, ʻo ka poʻe i lawe i ka quercetin he haʻahaʻa loa ka loaʻa ʻana o kahi maʻi viral ma hope o ka holo paikikala no ʻekolu hola i ka lā no ʻekolu mau lā i ka lālani. 45% o ka poʻe ma ka hui placebo i maʻi, ʻoiai he 5% wale nō o ka poʻe ma ka hui mālama i maʻi.

Ua kākoʻo kālā ka US Defense Advanced Research Projects Agency (DARPA) i kekahi noiʻi ʻē aʻe, i paʻi ʻia i ka makahiki 2008, a ua aʻo i ka hoʻohana ʻana i ka maʻi influenza H1N1 pathogenic loa e hoʻokūkū i nā holoholona i mālama ʻia me ka quercetin. ʻO ka hopena like nō ia, ʻoi aku ka haʻahaʻa o ka maʻi a me ka make o ka hui mālama ʻia ma mua o ka hui placebo. Ua hōʻoia pū kekahi mau noiʻi ʻē aʻe i ka pono o ka quercetin e kūʻē i nā ʻano maʻi like ʻole, me:

Ua ʻike ʻia kahi noiʻi i ka makahiki 1985 hiki i ka quercetin ke kāohi i ka maʻi a me ka hana hou ʻana o ka maʻi herpes simplex type 1, poliovirus type 1, parainfluenza virus type 3, a me ka respiratory syncytial virus.

Ua ʻike ʻia kahi noiʻi holoholona i ka makahiki 2010 hiki i ka quercetin ke kāohi i nā maʻi influenza A a me B. Aia kekahi mau ʻike nui ʻelua. ʻO ka mea mua, ʻaʻole hiki i kēia mau maʻi ke hoʻomohala i ke kūʻē ʻana i ka quercetin; ʻo ka lua, inā hoʻohana ʻia lākou me nā lāʻau antiviral (amantadine a i ʻole oseltamivir), hoʻonui nui ʻia ko lākou hopena - a ua pale ʻia ka ulu ʻana o ke kūʻē.

Ua ʻāpono ʻia kahi noiʻi holoholona i ka makahiki 2004 i kahi ʻano o ka maʻi H3N2, e noiʻi ana i ka hopena o ka quercetin i ka maʻi influenza. Ua kuhikuhi ka mea kākau:

"I ka wā o ka maʻi influenza, loaʻa ke kaumaha oxidative. Ma muli o ka hiki i ka quercetin ke hoʻihoʻi i ka nui o nā antioxidants he nui, manaʻo kekahi poʻe he lāʻau lapaʻau kūpono paha ia e hiki ke pale i nā māmā mai ka hoʻokuʻu ʻia ʻana i ka wā o ka maʻi influenza. ʻO nā hopena maikaʻi ʻole o nā radical free oxygen."

Ua ʻike ʻia kekahi noiʻi ʻē aʻe i ka makahiki 2016 hiki i ka quercetin ke hoʻoponopono i ka hōʻike ʻana o ka protein a he hopena pale ia i ka maʻi influenza H1N1. ʻO ke kikoʻī, ʻo ka hoʻoponopono ʻana o ka protein haʻalulu wela, fibronectin 1 a me ka protein inhibitory e kōkua i ka hōʻemi ʻana i ka hoʻonui ʻia ʻana o ka maʻi.

Ua ʻike ʻia ma ke kolu o ka noiʻi i paʻi ʻia ma 2016 hiki i ka quercetin ke kāohi i nā ʻano maʻi influenza like ʻole, me H1N1, H3N2, a me H5N1. Manaʻo ka mea kākau o ka hōʻike noiʻi, "Hōʻike kēia noiʻi e hōʻike ana ka quercetin i ka hana kāohi i ka wā mua o ka maʻi influenza, kahi e hāʻawi ai i kahi hoʻolālā lapaʻau kūpono i ka wā e hiki mai ana ma o ka hoʻomohala ʻana i nā lāʻau lapaʻau kūlohelohe kūpono, palekana, a me ke kumu kūʻai ʻole e mālama a pale aku i ka maʻi [Influenza A virus]."

I ka makahiki 2014, ua kuhikuhi nā kānaka noiʻi he "mea hoʻohiki ka quercetin i ka mālama ʻana i nā anu maʻamau i hoʻokumu ʻia e nā rhinoviruses" a hoʻohui ʻia, "Ua hōʻoia ka noiʻi hiki i ka quercetin ke hōʻemi i ka internalization a me ka hana hou ʻana o nā virus i loko o ka vitro. Hiki i ke kino ke hōʻemi i ka ukana viral, ka pneumonia a me ka hyperresponsiveness airway."

Hiki iā Quercetin ke hōʻemi i ka pōʻino oxidative, no laila e hōʻemi ana i ka pilikia o nā maʻi bacteria lua, ʻo ia ke kumu nui o nā make e pili ana i ka influenza. ʻO ka mea nui, hoʻonui ka quercetin i ka biosynthesis mitochondrial i loko o nā ʻiʻo iwi, e hōʻike ana i kahi hapa o kona hopena antiviral ma muli o ka hōʻailona antiviral mitochondrial i hoʻonui ʻia.

Ua ʻike ʻia i loko o kahi noiʻi holoholona i ka makahiki 2016 hiki i ka quercetin ke kāohi i ka maʻi dengue a me ka maʻi hepatitis i nā ʻiole. Ua hōʻoia pū kekahi mau noiʻi ʻē aʻe he hiki i ka quercetin ke kāohi i nā maʻi hepatitis B a me C.

I kēia mau lā iho nei, ua ʻike ʻia kahi noiʻi i paʻi ʻia ma ka puke pai Microbial Pathogenesis i Malaki 2020 hiki i ka quercetin ke hāʻawi i ka pale piha e kūʻē i ka maʻi Streptococcus pneumoniae ma vitro a ma vivo. He toxin (PLY) i hoʻokuʻu ʻia e ka pneumococcus e pale i ka puka ʻana o ka maʻi Streptococcus pneumoniae. Ma ka hōʻike "Microbial Pathogenesis", ua kuhikuhi ka mea kākau:

"Hōʻike nā hualoaʻa e hōʻemi nui ana ka quercetin i ka hana hemolytic a me ka cytotoxicity i hoʻokumu ʻia e PLY ma ke kāohi ʻana i ka hoʻokumu ʻia ʻana o nā oligomers.
Eia kekahi, hiki i ka mālama ʻana i ka quercetin ke hōʻemi i ka hōʻino ʻana o nā cell PLY-mediated, hoʻonui i ka nui o ke ola ʻana o nā ʻiole i loaʻa i ka maʻi make o Streptococcus pneumoniae, hōʻemi i ka hōʻino pathological o ka māmā, a kāohi i nā cytokines (IL-1β a me TNF) i ka hoʻokuʻu ʻana o ka wai lavage bronchoalveolar. -α.
Ke noʻonoʻo nei i ke koʻikoʻi o kēia mau hanana i ka pathogenesis o ka Streptococcus pneumoniae kūpaʻa, hōʻike kā mākou mau hopena e lilo paha ka quercetin i moho lāʻau lapaʻau hou no ka mālama ʻana i nā maʻi pneumococcal lapaʻau.
Hoʻouka ʻo Quercetin i ka mumū a hoʻonui i ka hana pale

Ma waho aʻe o ka hana antiviral, hiki i ka quercetin ke hoʻoikaika i ka pale ʻana a me ka hakakā ʻana i ka mumū. Ua kuhikuhi ʻia kahi noiʻi 2016 i paʻi ʻia ma ka puke pai Nutrients ʻo nā ʻano hana e komo pū ana (akā ʻaʻole i kaupalena ʻia i) ka pale ʻana i:

• ʻO ka Tumor necrosis factor alpha (TNF-α) i hoʻoulu ʻia e ka lipopolysaccharide (LPS) i loko o nā macrophages. ʻO TNF-α kahi cytokine e pili ana i ka mumū ʻōnaehana. Hoʻokuʻu ʻia ia e nā macrophages i hoʻāla ʻia. ʻO nā macrophages nā pūnaewele pale e hiki ke ale i nā mea haole, nā microorganism a me nā ʻāpana ʻino a hōʻino ʻia paha.
• Nā pae TNF-α a me interleukin (Il)-1α mRNA i hoʻoulu ʻia e Lipopolysaccharide i loko o nā pūnaewele glial, hiki ke alakaʻi i ka "hoʻemi ʻana o ka apoptosis o nā pūnaewele neuronal"
• Kāohi i ka hana ʻana o nā enzymes e hoʻoulu ai i ka mumū
• Kāohi i ke kahe ʻana o ka calcium i loko o nā pūnaewele, a laila e kāohi ana i:
◦ Hoʻokuʻu ʻia ʻana o nā cytokines pro-inflammatory
◦ Hoʻokuʻu nā pūnaewele mast o ka ʻōpū i ka histamine a me ka serotonin 

Wahi a kēia ʻatikala, hiki i ka quercetin ke hoʻopaʻa i nā pūnaewele mast, loaʻa ka hana cytoprotective ma ke ala gastrointestinal, a "loaʻa ka hopena hoʻoponopono pololei i nā ʻano hana kumu o nā pūnaewele pale", i hiki ai iā ia ke "hoʻohaʻahaʻa a kāohi paha i nā ʻano kahawai a me nā hana mumū," Kāohi i ka nui o nā pahuhopu molekala i ka pae hoʻohuihui micromolar".

Hiki i ka Quercetin ke lilo i mea hoʻopihapiha pono no nā poʻe he nui

Ma ka noʻonoʻo ʻana i nā pono like ʻole o ka quercetin, he mea hoʻohui pono paha ia no nā poʻe he nui, inā he pilikia koʻikoʻi a lōʻihi paha, hiki iā ia ke loaʻa kahi hopena. He mea hoʻohui kēia aʻu e paipai nei e mālama ʻoe i loko o ka pahu lāʻau. Hiki ke lilo i mea pono ke manaʻo ʻoe e "luhia" ʻia ʻoe e kahi pilikia olakino (inā he anu maʻamau a he maʻi palū paha).

Inā maʻalahi ʻoe i ka loaʻa ʻana o ke anu a me ka maʻi palū, hiki iā ʻoe ke noʻonoʻo e lawe i ka quercetin i kekahi mau mahina ma mua o ke kau anu a me ka maʻi palū e hoʻoikaika i kou ʻōnaehana pale. I ka wā lōʻihi, me he mea lā he mea pono loa ia no nā poʻe maʻi me ka metabolic syndrome, akā he mea lapuwale loa ke hilinaʻi wale i kekahi mau mea hoʻohui a hiki ʻole ke hoʻoponopono i nā pilikia kumu e like me ka ʻai a me ka hoʻoikaika kino i ka manawa like.