Ma waena o nā pepa hou loa e pili ana i kēia antioxidant ikaika he loiloi i paʻi ʻia ma Phytotherapy Research i Malaki 2019, nāna i loiloi i 9 mau mea e pili ana i nā hopena o ka quercetin ma ka metabolic syndrome Randomized controlled trial.

ʻO ka Metabolic Syndrome e pili ana i nā pilikia olakino e hoʻonui ai i ka pilikia o ka maʻi maʻi type 2, ka maʻi puʻuwai, a me ka hahau, me ke koko kiʻekiʻe, ke koko koko kiʻekiʻe, nā kiʻekiʻe triglyceride kiʻekiʻe, a me ka hōʻiliʻili momona o ka pūhaka.

ʻOiai ua ʻike ʻia nā haʻawina holoʻokoʻa ʻaʻohe hopena o ka quercetin i ka glucose koko hoʻokēʻai, ka pale ʻana o ka insulin a i ʻole ka pae hemoglobin A1c, ua hōʻike hou ʻia ka loiloi subgroup ua hoʻohui ʻia ka quercetin i nā haʻawina i lawe ma kahi o 500 mg i kēlā me kēia lā no ka liʻiliʻi o ʻewalu pule. Hoʻemi nui ʻia ka hoʻokē ʻai koko kō.

Kōkua ʻo Quercetin i ka hoʻoponopono ʻana i ka hōʻike gene

Wahi a kahi noiʻi i paʻi ʻia ma 2016, hiki i ka quercetin ke hoʻāla i ke kahawai mitochondrial o apoptosis (programmed cell death of damaged cell) ma o ka launa pū ʻana me DNA, a laila e hoʻihoʻi ai i ka tumor.

Ua ʻike nā haʻawina e hiki i ka quercetin ke hoʻoulu i ka cytotoxicity o nā cell leukemia, a pili ka hopena i ka hopena. Ua ʻike pū ʻia nā hopena cytotoxic liʻiliʻi i nā maʻi kanesa o ka umauma. Ma keʻano laulā, hiki i ka quercetin ke hoʻolōʻihi i ke ola o nā ʻiole maʻi maʻi e 5 mau manawa i hoʻohālikelike ʻia me ka hui mālama ʻole.

Hoʻopili nā mea kākau i kēia mau hopena i ka pilina pololei ma waena o ka quercetin a me ka DNA a me kāna hoʻāla ʻana i ke ala mitochondrial o apoptosis, a manaʻo ʻia ka hoʻohana ʻana o ka quercetin ma ke ʻano he lāʻau adjuvant no ka mālama ʻana i ka maʻi maʻi e pono e ʻimi hou aku.

ʻO kahi noiʻi hou i paʻi ʻia ma ka puke moʻolelo Molecules i hoʻoikaika pū i nā hopena epigenetic o quercetin a me kona hiki ke:

Ka launa pū ʻana me nā kaha hōʻailona kelepona
Hoʻoponopono i ka ʻōlelo gene
Hoʻopili i ka hana o nā mea transcription
Hoʻoponopono i ka microribonucleic acid (microRNA)

Ua manaʻo ʻia ka microribonucleic acid i ka DNA "junk". Ua ʻike nā haʻawina ʻaʻole pono ʻole ka "junk" DNA. He mole liʻiliʻi ʻo ia o ka waikawa ribonucleic, kahi hana koʻikoʻi i ka hoʻoponopono ʻana i nā genes e hana ai i nā protein kanaka.

Hiki ke hoʻohana ʻia ka microribonucleic acid ma ke ʻano he "hoʻololi" o kēia mau genes. Wahi a ka hoʻokomo ʻana o ka microribonucleic acid, hiki i kahi gene ke hoʻopili i kekahi o nā huahana protein ma mua o 200. Hiki i ka Quercetin ke hoʻololi i nā microRNAs hiki ke wehewehe i kona hopena cytotoxic a me ke kumu e hoʻonui ai i ke ola maʻi maʻi (ma ka liʻiliʻi no nā ʻiole).

ʻO Quercetin kahi mea antiviral ikaika

E like me ka mea i ʻōlelo ʻia ma luna, ʻo ka noiʻi i hana ʻia a puni ka quercetin e pili ana i kona hiki antiviral, ʻo ia ka mea ma muli o ʻekolu mau hana o ka hana:

Kāohi i ka hiki o nā maʻi maʻi ke hoʻopōʻino i nā pūnaewele
Kāohi i ka hana hou ʻana o nā maʻi maʻi
E ho'ēmi i ke kū'ēʻana o nā pūnaewele maʻi i ka lāʻau lapaʻau antiviral

No ka laʻana, he haʻawina i kākoʻo ʻia e ka US Department of Defense i paʻi ʻia i ka makahiki 2007 i ʻike ʻia ma hope o ka loaʻa ʻana o ke koʻikoʻi kino kino, hiki i ka quercetin ke hōʻemi i kou pilikia o ka loaʻa ʻana o ka maʻi maʻi a hoʻomaikaʻi i kāu hana noʻonoʻo, inā ʻaʻole ia e hōʻino i kāu hana immune , Hoʻolilo iā ʻoe i mea maʻalahi. i na mai.

I loko o kēia haʻawina, ua loaʻa i ka poʻe kaʻa kaʻa he 1000 mg o ka quercetin i ka lā, i hui pū ʻia me ka huaora C (hoʻonui i ka pae quercetin plasma) a me ka niacin (hoʻoulu i ka absorption) no ʻelima mau pule. Ua ʻike ʻia nā hopena i hoʻohālikelike ʻia me ka mālama ʻole ʻia No kēlā me kēia kaʻa kaʻa i mālama ʻia, ʻoi aku ka liʻiliʻi o ka poʻe i lawe i ka quercetin e loaʻa i kahi maʻi viral ma hope o ka holo ʻana i ke kaʻa no ʻekolu hola o ka lā no ʻekolu mau lā. ʻO 45% o ka poʻe i loko o ka hui placebo i maʻi, aʻo 5% wale nō o ka poʻe o ka hui lapaʻau i maʻi.

Ua kākoʻo kālā ka US Defense Advanced Research Projects Agency (DARPA) i kahi noiʻi ʻē aʻe, i paʻi ʻia i ka makahiki 2008, a ua aʻo i ka hoʻohana ʻana i ka maʻi maʻi H1N1 maʻi maʻi maʻi loa e hoʻohālikelike i nā holoholona i mālama ʻia me ka quercetin. Ua like ka hopena, ʻoi aku ka haʻahaʻa o ka maʻi a me ka make o ka hui lapaʻau ma mua o ka hui placebo. Ua hōʻoia ʻia nā haʻawina ʻē aʻe i ka pono o ka quercetin e kūʻē i nā ʻano maʻi like ʻole, e like me:

Ua ʻike ʻia kahi haʻawina ma 1985 hiki i ka quercetin ke kāohi i ka maʻi a me ka hoʻopiʻi ʻana o ka maʻi herpes simplex type 1, poliovirus type 1, parainfluenza virus type 3, a me respiratory syncytial virus.

Ua ʻike ʻia kahi noiʻi holoholona ma 2010 hiki i ka quercetin ke kāohi i nā maʻi maʻi influenza A a me B. Aia nō ʻelua ʻike nui. ʻO ka mea mua, ʻaʻole hiki i kēia mau maʻi ke hoʻomohala i ke kū'ē i ka quercetin; ʻO ka lua, inā hoʻohana pū ʻia lākou me nā lāʻau antiviral (amantadine a i ʻole oseltamivir), hoʻonui nui ʻia ko lākou hopena-a pale ʻia ka ulu ʻana o ke kū'ē.

Ua ʻae ʻia kahi noiʻi holoholona i ka makahiki 2004 i kahi maʻi maʻi H3N2, e noiʻi ana i ka hopena o ka quercetin ma ka maʻi maʻi maʻi. Ua kuhikuhi ka mea kākau:

"I ka wā o ka maʻi maʻi influenza, hiki mai ke koʻikoʻi oxidative. No ka mea hiki i ka quercetin ke hoʻihoʻi i ka manaʻo o nā antioxidants he nui, manaʻo kekahi poʻe he lāʻau maikaʻi ia e hiki ai ke pale aku i ka māmā mai ka hoʻokuʻu ʻia ʻana i ka maʻi maʻi influenza. ʻO nā hopena pōʻino o nā radical free oxygen. "

Ua ʻike ʻia kahi noiʻi ʻē aʻe i ka makahiki 2016 hiki i ka quercetin ke hoʻoponopono i ka hōʻike protein a loaʻa ka hopena pale i ka maʻi maʻi H1N1 influenza. Ma ke ʻano kikoʻī, ʻo ka hoʻoponopono ʻana i ka protein haʻalulu wela, fibronectin 1 a me ka protein inhibitory e kōkua i ka hōʻemi ʻana i ka maʻi maʻi.

Ua ʻike ʻia kahi haʻawina ʻekolu i paʻi ʻia ma 2016 hiki i ka quercetin ke kāohi i nā ʻano maʻi maʻi influenza, me H1N1, H3N2, a me H5N1. Manaʻo ka mea kākau o ka hōʻike noiʻi, "Ke hōʻike nei kēia haʻawina e hōʻike ana ka quercetin i ka hana inhibitory i ka wā mua o ka maʻi maʻi influenza, e hāʻawi ana i kahi hoʻolālā lapaʻau e hiki mai ana ma o ka hoʻomohala ʻana i nā lāʻau lapaʻau kūlohelohe kūpono, palekana, a me ke kumu kūʻai ʻole e mālama a pale aku [Influenza. He maʻi maʻi]."

I ka makahiki 2014, ua hōʻike ka poʻe noiʻi i ka quercetin "he mea hoʻohiki i ka mālama ʻana i ke anu maʻamau i hana ʻia e nā rhinoviruses" a hoʻohui ʻia, "Ua hōʻoia ka noiʻi e hiki i ka quercetin ke hōʻemi i ka internalization a me ka replication o nā maʻi i loko o vitro. Hiki i ke kino ke hōʻemi i ka viral load, pneumonia a me ka hyperresponsiveness ea."

Hiki i ka Quercetin ke hōʻemi i ka pōʻino oxidative, ma laila e hōʻemi ai i ka hopena o nā maʻi bacterial lua, ʻo ia ke kumu nui o ka make pili i ka influenza. ʻO ka mea nui, hoʻonui ka quercetin i ka biosynthesis mitochondrial i ka ʻiʻo skeletal, e hōʻike ana i ka ʻāpana o kāna hopena antiviral ma muli o ka hōʻailona antiviral mitochondrial i hoʻonui ʻia.

Ua ʻike ʻia kahi noiʻi holoholona ma 2016 hiki i ka quercetin ke kāohi i ka maʻi dengue a me ka maʻi maʻi hepatitis i nā ʻiole. Ua hōʻoia ʻia nā haʻawina ʻē aʻe he hiki i ka quercetin ke kāohi i ka maʻi hepatitis B a me C.

ʻO kēia manawa, kahi noiʻi i paʻi ʻia ma ka puke pai ʻo Microbial Pathogenesis i Malaki 2020 i ʻike hiki i ka quercetin ke hāʻawi i ka pale piha i ka maʻi Streptococcus pneumoniae ma ka vitro a me ka vivo. He lāʻau ʻawaʻawa (PLY) i hoʻokuʻu ʻia e ka pneumococcus e pale i ka puka ʻana o ka maʻi Streptococcus pneumoniae. Ma ka hōʻike "Microbial Pathogenesis", ua kuhikuhi ka mea kākau:

"Ke hōʻike nei nā hopena i ka hoʻemi nui ʻana o ka quercetin i ka hana hemolytic a me ka cytotoxicity i hoʻoiho ʻia e PLY ma ke kāohi ʻana i ka hoʻokumu ʻana o nā oligomers.
Eia hou, hiki i ka lāʻau quercetin ke hōʻemi i ka pōʻino o ka cell-mediated cell PLY, hoʻonui i ke ola o nā ʻiole i loaʻa i ka maʻi lethal o Streptococcus pneumoniae, hoʻemi i ka pōʻino pathological lung, a keʻakeʻa i nā cytokines (IL-1β a me TNF) i loko o ka wai holoi bronchoalveolar. -α) hoʻokuʻu.
Ke noʻonoʻo nei i ke koʻikoʻi o kēia mau hanana i ka pathogenesis o Streptococcus pneumoniae kū'ē, hōʻike kā mākou mau hopena e lilo paha ka quercetin i moho lāʻau hou no ka mālama ʻana i nā maʻi pneumococcal clinical. "
ʻO Quercetin e hakakā i ka mumū a hoʻonui i ka hana immune

Ma waho aʻe o ka hana antiviral, hiki i ka quercetin ke hoʻoikaika i ka pale a hakakā i ka mumū. Ua hōʻike ʻia kahi haʻawina 2016 i paʻi ʻia ma ka puke pai Nutrients e pili ana nā hana o ka hana (akā ʻaʻole i kaupalena ʻia) i ka pale ʻana o:

• Tumor necrosis factor alpha (TNF-α) i hoʻouluʻia e ka lipopolysaccharide (LPS) i loko o nā macrophages. ʻO TNF-α kahi cytokine e pili ana i ka mumū ʻōnaehana. Ua huna ʻia e nā macrophages i hoʻāla ʻia. ʻO Macrophages nā pūnaewele pale e hiki ke ale i nā mea ʻē aʻe, nā microorganisms a me nā mea ʻino a i ʻole nā ​​​​mea pōʻino.
• Lipopolysaccharide-induced TNF-α a me interleukin (Il)-1α mRNA pae i loko o glial pūnaewele, hiki ke alakai i ka "hōʻemi neuronal cell apoptosis"
• Kāohi i ka hana ʻana o nā enzyme e hoʻoulu ai i ka mumū
• Kāohi i ke kahe ʻana o ka calcium i loko o nā pūnaewele, a laila e pale ai:
◦ Hoʻokuʻu i nā cytokine pro-inflammatory
◦ Hoʻokuʻu nā pūpū mast intestinal i ka histamine a me ke serotonin 

Wahi a kēia ʻatikala, hiki i ka quercetin ke hoʻopaʻa i nā mast cell, he hana cytoprotective ma ka ʻōpū o ka ʻōpū, a "loaʻa ka hopena hoʻoponopono pololei i nā ʻano hana pono o nā cell immune", i hiki iā ia ke "hoʻohaʻahaʻa a pale i nā ʻano like ʻole. nā ala inflammatory a me nā hana, "Kaohi i ka nui o nā molecular targets i ka micromolar concentration range".

ʻO Quercetin paha he mea kōkua pono no nā poʻe he nui

I ka noʻonoʻo ʻana i ka nui o nā pono o ka quercetin, hiki ke lilo i mea hoʻohui maikaʻi no nā poʻe he nui, inā he pilikia koʻikoʻi a lōʻihi paha, hiki ke loaʻa kekahi hopena. ʻO kēia kekahi mea hoʻohui aʻu e paipai nei e mālama ʻoe i loko o ke keʻena lāʻau lapaʻau. Hiki ke hoʻohana ʻia ke manaʻo ʻoe ua kokoke ʻoe e "hoʻopilikia ʻia" e kahi pilikia olakino (inā he anu maʻamau a i ʻole ka maʻi maʻi).

Inā hiki iā ʻoe ke loaʻa i ke anu a me ka maʻi maʻi, hiki iā ʻoe ke noʻonoʻo e lawe i ka quercetin i kekahi mau mahina ma mua o ke kau anuanu a me ka maʻi maʻi e hoʻoikaika i kou ʻōnaehana pale. I ka wā lōʻihi, ʻike ʻia he mea maikaʻi loa ia no nā poʻe maʻi me ka metabolic syndrome, akā he mea lapuwale ke hilinaʻi wale i kekahi mau mea hoʻohui a hiki ʻole ke hoʻoponopono i nā pilikia kumu e like me ka ʻai a me ka hoʻoikaika kino i ka manawa like.