ʻO ke kanesa māmā ka lua o ke ʻano maʻamau o ke kanesa ma ka honua. I ka makahiki 2020, ʻoi aku ma mua o 2.2 miliona mau kānaka ma ka honua holoʻokoʻa e ʻike ʻia me ke kanesa māmā no ka manawa mua. I ka makahiki hoʻokahi, ua make ma kahi o 1.8 miliona mau kānaka ma ka honua holoʻokoʻa i ke kanesa māmā.
ʻOiai ʻaʻohe lāʻau lapaʻau no ka maʻi kanesa māmā i kēia manawa, ke hana nei nā kānaka ʻepekema i nā koho lapaʻau. Hana kekahi o kēia mau kānaka ʻepekema ma ke Kulanui o Technology Sydney (UTS), kahi i hōʻike ai kahi noiʻi hou e hiki i kahi hui mea kanu kūlohelohe i kapa ʻia ʻo berberine ke hoʻōki i ka ulu ʻana o nā hunaola kanesa māmā i loko o ka hale hana.
He mea kanu kūlohelohe ʻo Berberine i hoʻohana ʻia i ka lāʻau lapaʻau kuʻuna Kina no nā tausani makahiki. Loaʻa ia i nā ʻano mea kanu like ʻole, me ka barberry, goldenseal, Oregon grape, a me ka turmeric lāʻau.

(ʻO kā mākou huahanaʻO ka ʻāpana Berberine, me ka mahalo e nīnau mai.)

Ua hōʻike ʻia nā makahiki o ka noiʻi ʻana he pono ka berberine i ke kōkua ʻana i nā poʻe me ka maʻi diabetes type 2 e hoʻoponopono i ko lākou pae kō koko a hiki ke kōkua i ka mālama ʻana i ka metabolic syndrome.
Ua ʻike pū nā kānaka noiʻi hiki ke hoʻohana ʻia ka berberine e mālama i nā ʻano maʻi kanesa like ʻole, me ka maʻi ovarian, ka ʻōpū, a me ka umauma.
Wahi a Kauka Kamal Dua, Luna Hoʻonaʻauao Kiʻekiʻe a me ka Hoa Noiʻi Kiʻekiʻe ma ka Hale Lapaʻau ma ke Kikowaena Noiʻi o Australia no ka Lapaʻau Hoʻohui a me ka Hoʻohui (ARCCIM), ke Kula Lapaʻau o ke Kulanui o Technology Sydney (UTS) a me ke alakaʻi o ke aʻo ʻana, ua kāohi ʻo Berberine i ʻelua mau kaʻina hana koʻikoʻi i ka ulu ʻana o ka maʻi kanesa - ka hoʻolaha ʻana a me ka neʻe ʻana o nā cell.
"Ma ke ʻano mīkini, hiki ke hoʻokō ʻia kēia ma o ke kāohi ʻana i nā genes koʻikoʻi e like me P53, PTEN a me KRT18 a me nā protein e like me AXL, CA9, ENO2, HER1, HER2, HER3, PRGN, PDGF-AA, DKK1, CTSB, CTSD, BCLX, CSF1. a me CAPG e pili ana i ka hoʻonui ʻana a me ka neʻe ʻana o nā cell cancer," wahi āna.
Ma ke aʻo ʻana o kēia manawa, ua aʻo kahi hui noiʻi e komo pū ana me Kauka Dua, Kauka Keshav Raj Paudel, Polofesa Philip M. Hansbrough lāua ʻo Kauka Bikash Manandhar o UTS, a me nā limahana mai ke Kulanui Lapaʻau ʻo Malaysian International a me ke Kulanui ʻo Al Qasim ma Saudi Arabia, pehea e hiki ai ke hoʻohana ʻia ka berberine no ka mālama ʻana i ka maʻi ʻaʻai māmā.
"Ua kaupalena ʻia ka hoʻohana ʻana o ka berberine ma ke ʻano lapaʻau ma muli o kona solubility maikaʻi ʻole a me ka bioavailability," wahi a Kauka Dua no MNT. "ʻO ka pahuhopu nui o kēia noiʻi ʻana, ʻo ia ka hoʻomaikaʻi ʻana i nā ʻano physicochemical o ka berberine ma ka hoʻololi ʻana i ka berberine i nā nanoparticles kristal wai a e ʻimi i kona hiki ke anticancer in vitro ma nā cell basal epithelial alveolar o ka adenocarcinoma kanaka A549."
Ua hoʻomohala ka hui noiʻi i kahi ʻōnaehana lawe lāʻau holomua e hoʻopuni ana i ka berberine i loko o nā spheres liʻiliʻi hiki ke hoʻoheheʻe ʻia a biodegradable. Ua hoʻohana ʻia kēia mau nanoparticles kristal wai e mālama i nā ʻōpū kanesa o ke kanaka ma vitro i loko o ka hale hana.
I ka hopena o ke aʻo ʻana, ua ʻike ka hui ua kōkua ka berberine i ka pale ʻana i ka hana ʻana o nā ʻano oxygen reactive, nā kemika inflammatory i hana ʻia e kekahi mau cell i ka pane ʻana i ka hoʻouka kaua bacteria a me nā hanana hoʻoluhi ʻē aʻe e hiki ai ke hōʻino i nā cell.
Eia kekahi, kōkua ʻo berberine i ka hoʻoponopono ʻana i nā genes e pili ana i ka hoʻoluhi oxidative a me ka mumū, a kōkua i ka hōʻemi ʻana i ka ʻelemakule mua o nā cell.
"Ua hōʻike mākou, me ka hoʻohana ʻana i kahi ala nanotechnological, hiki ke hoʻomaikaʻi ʻia nā waiwai o ka hui e hoʻoponopono i nā pilikia like ʻole e pili ana i ka solubility, cellular uptake, a me ka therapeutic efficacy," wahi a Kauka Dua. Anticancer Potential Ua hōʻike kā mākou berberine liquid crystal nanoparticles i ka hana like ma ʻelima mau manawa o ka nui i hoʻohālikelike ʻia me nā palapala i paʻi ʻia, e hōʻike maopopo ana i nā pono o nā nanodrugs.
No ka hoʻāʻo hou ʻana i kēia mau hopena, ua ʻōlelo ʻo Kauka Dua ua hoʻolālā ʻo ia e hoʻohana i ka paepae noiʻi hou e hana i nā haʻawina hohonu e hoʻohana ana i nā hiʻohiʻona holoholona preclinical o ka maʻi kanesa māmā.
"ʻO nā haʻawina pharmacokinetic a me nā anticancer hou aʻe o nā nanodrugs berberine i nā hiʻohiʻona holoholona in vivo e hōʻike i ko lākou mau pono kūpono i ka mālama ʻana i ka maʻi kanesa māmā a hoʻolilo iā lākou i nā ʻano dosage therapeutic," wahi āna.
"Ke hōʻoia mākou i ka hiki ke kū'ē i ka maʻi kanesa o nā nanodrugs berberine i nā hiʻohiʻona holoholona preclinical, ʻo ka hana aʻe e neʻe i nā hoʻokolohua lapaʻau, kahi a mākou e kūkākūkā nei me kekahi mau ʻoihana ma Sydney," wahi a Kauka Dua.
Eia kekahi, ua ʻōlelo ʻo Kauka Dua e pono e hōʻoia ʻia ka hiki o ka berberine ke pale i ka hoʻi hou ʻana o ka maʻi kanesa māmā: "ʻOiai ʻaʻole mākou i noiʻi i kēia, ke hoʻolālā nei mākou e aʻo iā ia i nā haʻawina e hiki mai ana, a ke manaʻoʻiʻo nei hoʻi mākou e hōʻike nā nanoforms berberine i ka hana hoʻohiki."
Ua haʻi aku ʻo Kauka Osita Onuga, ke kauka ʻoki thoracic a me ke polopeka kōkua o ke ʻoki thoracic ma ka St. John Cancer Institute ma Providence St. John Medical Center ma Santa Monica, Kaleponi, iā MNT i ka wā e loaʻa ai i nā mea noiʻi nā manawa hou e mālama ai a pale aku i ka maʻi kanesa, aia mau ka manaʻolana:
"He ʻāpana ʻo Berberine o ka lāʻau lapaʻau Hikina, no laila ʻaʻole mākou e hoʻohana maʻamau iā ia i ka lāʻau lapaʻau Komohana. Manaʻo wau he mea hoihoi ia no ka mea ke nānā nei mākou i nā mea a mākou i ʻike ai he mau pono no nā mea lāʻau lapaʻau Hikina, a hoʻokomo iā ia i loko o ka noiʻi e kōkua i ka unuhi ʻana i kēlā i ka lāʻau lapaʻau Komohana."
"He mea hoʻohiki mau ia, akā aia i loko o ka lab, a ʻo ka nui o nā mea a mākou e ʻike ai i loko o ka lab ʻaʻole ia e alakaʻi i ka mālama ʻia ʻana o nā maʻi," hoʻomau ʻo Onuga. "Manaʻo wau ʻo ka mea aʻe e hana ai, ʻo ia ke hana i kekahi mau hoʻokolohua lapaʻau ma nā maʻi a noʻonoʻo i ka nui o ka lāʻau."
Loaʻa i kekahi poʻe nā hōʻailona malū o ka maʻi kanesa māmā i nā pae mua o ka maʻi. E heluhelu e aʻo hou aʻe, me ka wā e ʻike ai i ke kauka.
ʻOkoʻa ka nui o ka maʻi kanesa o ka māmā i nā wahine a me nā kāne, akā like nā hōʻailona a me nā kumu pilikia. Maanei mākou e wehewehe nei i nā ʻano genetic a me nā hormonal…
He mea hana ʻoihana mākou no ka pauka ʻōpala mea kanu, e ʻoluʻolu e hoʻouna i kāu mau nīnau e pili ana i kā mākou huahana a he hoa hana ko mākou e hoʻoponopono i kāu mau pilikia e pili ana i ke kūʻai mua a me ke kūʻai aku ma hope. E kāhea iā mākou i kēlā me kēia manawa!!!