ʻO kahi mea hoʻohui i kapa ʻia ʻo 5-hydroxytryptophan (5-HTP) a i ʻole osetriptan i manaʻo ʻia kekahi o nā lāʻau lapaʻau ʻē aʻe no ka maʻi poʻo a me ka migraines.Hoʻololi ke kino i kēia mea i serotonin (5-HT), i kapa ʻia ʻo serotonin, kahi neurotransmitter e hoʻoponopono i ke ʻano a me ka ʻeha.
ʻIke pinepine ʻia nā haʻahaʻa serotonin haʻahaʻa i ka poʻe me ke kaumaha, akā ʻo ka poʻe maʻi migraine a me ka poʻe maʻi maʻi poʻo maʻi hiki ke loaʻa i nā pae serotonin haʻahaʻa i ka wā a ma waena o nā hoʻouka ʻana.ʻAʻole maopopo i ke kumu e pili ai ka migraines a me ke serotonin.ʻO ka manaʻo kaulana loa, ʻo ka hemahema o ke serotonin e hoʻolilo i ka poʻe hypersensitive i ka ʻeha.
Ma muli o kēia pilina, hoʻohana mau ʻia kekahi mau ʻano o ka hoʻonui ʻana i ka hana serotonin i loko o ka lolo no ka pale ʻana i ka migraines a mālama i nā hōʻeha koʻikoʻi.
ʻO 5-HTP kahi amino acid i hana ʻia e ke kino mai ka waikawa amino koʻikoʻi L-tryptophan a pono e loaʻa mai ka meaʻai.Loaʻa ka L-tryptophan i nā meaʻai e like me nā hua, soybeans, turkey a me ka paʻakai.Hoʻololi maoli nā enzyme i ka L-tryptophan i 5-HTP, a laila hoʻololi i ka 5-HTP i 5-HT.
Hana ʻia nā mea hoʻohui 5-HTP mai ka lāʻau lapaʻau West Africa ʻo Griffonia simplicifolia.Ua hoʻohana ʻia kēia kumulāʻau no ka mālama ʻana i ke kaumaha, ka fibromyalgia, ka maʻi luhi mau loa, a no ka pohō kaumaha, akā ʻaʻohe hōʻike paʻa o kāna mau pono.
Ke noʻonoʻo nei i ka 5-HTP a i ʻole nā ​​​​mea hoʻohui kūlohelohe, he mea nui e hoʻomaopopo he mau kemika kēia mau huahana.Inā ʻoe e lawe iā lākou no ka mea ua lawa lākou e loaʻa ai ka hopena maikaʻi i kou olakino, e hoʻomanaʻo e hiki nō hoʻi iā lākou ke lawa ka ikaika e loaʻa ai nā hopena maikaʻi ʻole.
ʻAʻole maopopo inā pono nā mea hoʻohui 5-HTP no ka migraines a i ʻole nā ​​​​ʻano ʻeha ʻē aʻe.Ma keʻano holoʻokoʻa, ua kaupalena ʻia ka noiʻi;ʻO kekahi mau haʻawina e hōʻike ana he kōkua ia, aʻo nā mea ʻē aʻe ʻaʻohe hopena.
Ua hoʻohana nā haʻawina Migraine i nā doses o 5-HTP mai 25 a 200 mg i kēlā me kēia lā i nā pākeke.I kēia manawa ʻaʻohe mea maopopo a ʻōlelo ʻia paha no kēia kumulāʻau, akā pono e hoʻomaopopo ʻia e pili ana nā kiʻekiʻe kiʻekiʻe me nā hopena ʻaoʻao a me nā pilina lāʻau.
Hiki i ka 5-HTP ke launa pū me kekahi mau lāʻau lapaʻau, me ka carbidopa, i hoʻohana ʻia e mālama i ka maʻi o Parkinson.Hiki iā ia ke launa pū me nā triptans, SSRI, a me nā mea hoʻopaneʻe monoamine oxidase (MAOI, kekahi papa o nā antidepressants).
Hiki ke hoʻohaumia ʻia ka tryptophan a me ka 5-HTP me ka mea kūlohelohe 4,5-tryptophanione, kahi neurotoxin i kapa ʻia ʻo Peak X. ʻO nā hopena inflammatory o Peak X hiki ke hoʻoulu i ka ʻeha o ka ʻiʻo, cramping, a me ke kuni.Hiki i nā hopena lōʻihi ke komo i ka ʻiʻo a me ke aʻalolo.
No ka mea, ʻo kēia kemika he hopena o ka hopena kemika a ʻaʻole ia he haumia a i ʻole he mea haumia, hiki ke loaʻa i loko o nā mea hoʻohui inā ua mākaukau lākou ma lalo o nā kūlana maʻemaʻe.
He mea nui e kūkākūkā i ka lawe ʻana i nā mea hoʻopihapiha me kāu kauka a lāʻau lapaʻau paha i mea e palekana ai lākou no ʻoe a ʻaʻole e launa pū me kāu mau lāʻau lapaʻau ʻē aʻe.
E hoʻomanaʻo ʻaʻole i hoʻopaʻa ʻia nā mea hoʻohui meaʻai a me nā lāʻau lapaʻau e like me ka hoʻopaʻa ʻana a me ka hoʻāʻo ʻana e like me nā lāʻau lapaʻau a me nā lāʻau lapaʻau, ʻo ia hoʻi, ʻo ka noiʻi e kākoʻo ana i ka pono a me ka palekana i kaupalena ʻia a pau ʻole.
Hiki ke nani nā mea hoʻohui a me nā lāʻau lapaʻau maoli, ʻoiai inā ʻaʻohe hopena ʻaoʻao.ʻO ka ʻoiaʻiʻo, ua hōʻoia ʻia nā lāʻau lapaʻau kūlohelohe no nā maʻi he nui.Aia nā hōʻike e hiki i nā mea hoʻohui magnesium ke hoʻemi i ka pinepine a me ka paʻakikī o nā hōʻeha migraine.Eia naʻe, ʻaʻole maopopo inā he pono ka 5-HTP no ka migraines.
ʻO Horvath GA, Selby K, Poskitt K, a me al.ʻO nā kaikunāne me nā haʻahaʻa serotonin ʻōnaehana haʻahaʻa e hoʻomohala i ka migraine hemiplegic, ka hopu ʻana, ka paraplegia spastic holomua, nā maʻi naʻau, a me ka coma.ʻeha poʻo.2011;31(15):1580-1586.Helu: 10.1177/0333102411420584.
Aggarwal M, Puri V, Puri S. Serotonin a me CGRP i ka migraine.Ann Neuroscience.2012;19(2):88–94.doi:10.5214/ans.0972.7531.12190210
Chauvel V, Moulton S, Chenin J. Estrogen e pili ana i nā hopena o 5-hydroxytryptophan i ka hoʻolaha ʻana i ke kaumaha cortical i nā ʻiole: hoʻohālike i ka pilina o ke serotonin a me ka hormone ovarian i ka migraine aura.ʻeha poʻo.2018;38(3):427-436.Helu: 10.1177/0333102417690891
Victor S., Ryan SV Nā lāʻau lapaʻau no ka pale ʻana i ka migraine i nā keiki.Cochrane Database Syst Rev 2003;(4):CD002761.Helu: 10.1002/14651858.CD002761
Das YT, Bagchi M., Bagchi D., Preus HG Palekana o 5-hydroxy-L-tryptophan.Nā leka e pili ana i ka toxicology.2004;150(1):111-22.doi:10.1016/j.toxlet.2003.12.070
ʻO Teri Robert He mea kākau ʻo Teri Robert, kumu hoʻonaʻauao hoʻomanawanui, a me ke kākoʻo hoʻomanawanui e ʻike ana i ka migraines a me ke poʻo.