ʻO kahi pākuʻi i kapa ʻia ʻo 5-hydroxytryptophan (5-HTP) a i ʻole osetriptan i manaʻo ʻia ʻo ia kekahi o nā lāʻau lapaʻau ʻē aʻe no nā poʻo ʻeha a me nā migraines. Hoʻololi ke kino i kēia mea i serotonin (5-HT), i ʻike ʻia hoʻi ʻo serotonin, kahi neurotransmitter e hoʻoponopono i ke ʻano a me ka ʻeha.
ʻIke pinepine ʻia nā pae serotonin haʻahaʻa i nā poʻe me ke kaumaha, akā hiki i ka poʻe maʻi migraine a me nā poʻo ʻeha mau ke ʻike i nā pae serotonin haʻahaʻa i ka wā a ma waena o nā hoʻouka kaua. ʻAʻole maopopo ke kumu e pili ai ka migraines a me ka serotonin. ʻO ke kumumanaʻo kaulana loa, ʻo ka nele o ka serotonin e hoʻolilo i ka poʻe i hypersensitive i ka ʻeha.
Ma muli o kēia pilina, hoʻohana pinepine ʻia kekahi mau ʻano hana e hoʻonui ai i ka hana serotonin i loko o ka lolo e pale aku i nā migraines a mālama i nā hoʻouka kaua koʻikoʻi.
ʻO 5-HTP kahi waikawa amino i hana ʻia e ke kino mai ka waikawa amino koʻikoʻi L-tryptophan a pono e loaʻa mai ka meaʻai. Loaʻa ka L-tryptophan i nā meaʻai e like me nā hua, nā soybeans, ka pelehū a me ka tīhi. Hoʻololi maoli nā enzymes i ka L-tryptophan i 5-HTP, a laila hoʻololi i ka 5-HTP i 5-HT.
Hana ʻia nā mea hoʻohui 5-HTP mai ka mea kanu lāʻau lapaʻau ʻApelika Komohana ʻo Griffonia simplicifolia. Ua hoʻohana ʻia kēia mea hoʻohui e mālama i ke kaumaha, fibromyalgia, ka maʻi luhi mau, a no ka pohō kaumaha, akā ʻaʻohe hōʻike paʻa o kona mau pono.
I ka noʻonoʻo ʻana i ka 5-HTP a i ʻole kekahi mea hoʻohui kūlohelohe, he mea nui e hoʻomaopopo he mau kemika kēia mau huahana. Inā ʻoe e lawe iā lākou no ka mea ua lawa ko lākou ikaika e loaʻa ai ka hopena maikaʻi i kou olakino, e hoʻomanaʻo he hiki nō hoʻi iā lākou ke lawa ka ikaika e loaʻa ai nā hopena maikaʻi ʻole.
ʻAʻole maopopo inā he pono nā mea hoʻohui 5-HTP no nā migraines a i ʻole nā ​​ʻano ʻeha poʻo ʻē aʻe. Ma keʻano holoʻokoʻa, ua kaupalena ʻia ka noiʻi; hōʻike kekahi mau haʻawina he kōkua ia, aʻo kekahi e hōʻike ʻole i ka hopena.
Ua hoʻohana nā haʻawina migraine i nā mahele o 5-HTP mai 25 a 200 mg i kēlā me kēia lā i nā pākeke. ʻAʻohe mahele maopopo a i ʻōlelo ʻia paha no kēia pākuʻi i kēia manawa, akā he mea kūpono ke hoʻomaopopo ʻana ua pili nā mahele kiʻekiʻe me nā hopena ʻaoʻao a me nā pilina lāʻau.
Hiki i ka 5-HTP ke launa pū me kekahi mau lāʻau lapaʻau, me ka carbidopa, ka mea i hoʻohana ʻia e mālama i ka maʻi o Parkinson. Hiki nō hoʻi iā ia ke launa pū me nā triptans, SSRIs, a me nā monoamine oxidase inhibitors (MAOIs, kekahi papa o nā antidepressants).
Hiki ke haumia ʻia nā mea hoʻohui Tryptophan a me 5-HTP me ka mea kūlohelohe 4,5-tryptophanione, kahi neurotoxin i ʻike ʻia ʻo Peak X. Hiki i nā hopena mumū o Peak X ke hoʻoulu i ka ʻeha o nā ʻiʻo, ka ʻūlū, a me ke kuni. Hiki i nā hopena lōʻihi ke komo pū me ka hōʻino ʻana o nā ʻiʻo a me nā aʻalolo.
No ka mea, he huahana ʻaoʻao kēia kemika o kahi hopena kemika a ʻaʻole ia he haumia a mea haumia paha, hiki ke loaʻa i loko o nā mea hoʻopihapiha ʻoiai inā ua hoʻomākaukau ʻia lākou ma lalo o nā kūlana maʻemaʻe.
He mea nui e kūkākūkā i ka lawe ʻana i nā mea hoʻopihapiha me kāu kauka a kauka lāʻau paha e hōʻoia i ka palekana iā ʻoe a ʻaʻole e launa pū me kāu mau lāʻau lapaʻau ʻē aʻe.
E hoʻomanaʻo ʻaʻole i hana ʻia nā mea hoʻopihapiha meaʻai a me nā mea kanu i ke aʻo like ʻana a me ka hoʻāʻo ʻana e like me nā lāʻau lapaʻau ma luna o ka counter a me nā lāʻau lapaʻau, ʻo ia hoʻi ua kaupalena ʻia a ʻaʻole piha paha ka noiʻi e kākoʻo ana i ko lākou pono a me ka palekana.
Hiki i nā mea hoʻohui a me nā lāʻau lapaʻau kūlohelohe ke lilo i mea hoihoi, ʻoiai inā ʻaʻohe o lākou hopena ʻaoʻao. ʻO kaʻoiaʻiʻo, ua hōʻoia ʻia nā lāʻau lapaʻau kūlohelohe he pono no nā maʻi he nui. Aia nā hōʻike e hiki i nā mea hoʻohui magnesium ke hōʻemi i ka alapine a me ke koʻikoʻi o nā hoʻouka migraine. Eia nō naʻe, ʻaʻole maopopo inā he pono ka 5-HTP no nā migraines.
ʻO Horvath GA, ʻo Selby K, ʻo Poskitt K, et al. ʻO nā hoahānau me nā pae serotonin systemic haʻahaʻa e hoʻomohala i ka migraine hemiplegic, nā hopu ʻana, ka paraplegia spastic holomua, nā maʻi ʻano, a me ka coma. ʻEha poʻo. 2011;31(15):1580-1586. Helu: 10.1177/0333102411420584.
ʻAggarwal M, Puri V, Puri S. Serotonin a me CGRP i ka migraine. Ann Neuroscience. 2012;19(2):88–94. doi:10.5214/ans.0972.7531.12190210
ʻO Chauvel V, Moulton S, Chenin J. Nā hopena e pili ana i ka Estrogen o 5-hydroxytryptophan i ka hoʻolaha ʻana i ke kaumaha cortical i nā ʻiole: ke hoʻohālike nei i ka pilina o ka serotonin a me ka hormone ovarian i ka migraine aura. ʻEha poʻo. 2018;38(3):427-436. Helu: 10.1177/0333102417690891
ʻO Victor S., Ryan SV Nā lāʻau lapaʻau no ka pale ʻana i ka migraine i nā keiki. Cochrane Database Syst Rev 2003;(4):CD002761. Helu: 10.1002/14651858.CD002761
ʻO Das YT, Bagchi M., Bagchi D., Preus HG Palekana o 5-hydroxy-L-tryptophan. Nā leka ma ka toxicology. 2004;150(1):111-22. doi:10.1016/j.toxlet.2003.12.070
ʻO Teri Robert he mea kākau ʻo Teri Robert, he kumu aʻo hoʻomanawanui, a he mea kākoʻo hoʻomanawanui i loea i ka migraines a me nā ʻeha poʻo.