Hoʻohana mākou i nā kuki e hoʻomaikaʻi i kou ʻike.Ma ka hoʻomau ʻana i kēia pūnaewele, ʻae ʻoe i kā mākou hoʻohana ʻana i nā kuki.ʻIke hou aku.
Ma ke kaomi ʻana i ka "Allow All", ʻae ʻoe i ka mālama ʻana i nā kuki ma kāu hāmeʻa e hoʻomaikaʻi i ka hoʻokele pūnaewele, ka nānā ʻana i ka hoʻohana ʻana i ka pūnaewele, a kākoʻo i kā mākou hāʻawi ʻana i ka ʻike ʻepekema manuahi.ʻIke hou aku.
I loko o kahi noiʻi hou i paʻi ʻia ma ka puke pai Pharmaceutics, ua hoʻoholo nā mea noiʻi i ka hopena antimicrobial o kahi lāʻau lapaʻau i kapa ʻia ʻo FRO e kūʻē i ka pathogenesis acne.
Ua hōʻike ʻia ka loiloi antimicrobial a me ka nānā ʻana in vitro he nui nā hopena antibacterial a anti-inflammatory iā FRO e kūʻē iā Dermatobacillus Acnes (CA), he hua bacteria e hoʻoulu ai i ka haki.Hōʻike kēia mau hopena i kona hoʻohana palekana a kūlohelohe i ka hoʻomaʻamaʻa ʻana i ka ʻeʻe, e kākoʻo ana i ka hoʻohana ʻana i nā mea ʻawaʻawa a me ke kumu kūʻai i nā lāʻau lapaʻau o kēia manawa.
Haʻawina: ʻO ka maikaʻi o FRO i ka pathogenesis o ka acne vulgaris.Kiʻi kiʻi: Steve Jungs/Shutterstock.com
ʻO Acne vulgaris, i kapa ʻia ʻo nā pimples, he maʻi ʻili maʻamau i hoʻokumu ʻia e nā follicles lauoho paʻa me ka sebum a me nā ʻili ʻili make.ʻOi aku ka maʻi o ka Acne ma mua o 80 pakeneka o ka poʻe ʻōpio a, ʻoiai ʻaʻole ia he mea make, hiki ke hoʻopilikia i ka noʻonoʻo a, i nā hihia koʻikoʻi, ka pigmentation mau a me ka ʻili ʻili.
Loaʻa ka ʻāʻī mai kahi pilina o nā ʻano genetic a me ke kaiapuni, i hana pinepine ʻia e nā loli hormonal e hele pū me ka wā ʻōpio.Hoʻonui kēia mau ʻano hormonal i ka hana sebum a hoʻonui i ka insulin growth factor 1 (IGF-1) a me ka hana dihydrotestosterone (DHT).
ʻO ka hoʻonui ʻia ʻana o ka sebum huna i manaʻo ʻia ʻo ka pae mua o ka hoʻomohala ʻana i ka haki, no ka mea, ʻo nā follicles lauoho i hoʻopiha ʻia me ka sebum he nui nā microorganisms e like me SA.ʻO ka SA kahi mea commensal maoli o ka ʻili;akā naʻe, hoʻonui ʻia ka hoʻonui ʻana o kāna phylotype IA1 e hoʻoulu ai i ka mumū a me ka pigmentation o nā follicles lauoho me nā papules ʻike ʻia i waho.
Aia nā lāʻau lapaʻau like ʻole no ka haki, e like me ka retinoids a me nā mea hana microbial topical, i hoʻohana pū ʻia me nā peels kemika, laser/light therapy, a me nā mea hana hormonal.Eia nō naʻe, ʻano pipiʻi kēia mau lāʻau lapaʻau a pili pū me nā hopena ʻino.
Ua ʻimi nā haʻawina mua i nā mea kanu lāʻau ma ke ʻano he kumu kūʻai kūʻai kūlohelohe i kēia mau lāʻau lapaʻau.Ma ke ʻano he ʻokoʻa, ua aʻo ʻia nā ʻāpana Rhus vulgaris (RV).Eia naʻe, ua kaupalena ʻia kona hoʻohana ʻana e ka urushiol, kahi mea allergenic nui o kēia kumulāʻau.
ʻO ka FRO kahi mea kanu lāʻau i loaʻa nā ʻāpana fermented o RV (FRV) a me Japanese mangosteen (OJ) ma kahi ratio 1:1.Ua hoʻāʻo ʻia ka maikaʻi o ke ʻano me ka hoʻohana ʻana i nā in vitro assays a me nā waiwai antimicrobial.
Ua ʻike mua ʻia ka hui ʻana o FRO me ka hoʻohana ʻana i ka chromatography wai hana kiʻekiʻe (HPLC) e hoʻokaʻawale, ʻike a helu i kona mau ʻāpana.Hoʻopili hou ʻia ka hui ʻana no ka huina phenolic content (TPC) e ʻike ai i nā pūhui i loaʻa nā waiwai antimicrobial.
Hoʻomaka mua in vitro antimicrobial assay ma ka nānā ʻana i ka ʻike diffusion disc.ʻO ka mua, ua hoʻoulu like ʻia ʻo CA (phylotype IA1) ma luna o kahi pā agaru kahi i kau ʻia ai kahi disk pepa kānana FRO-impregnated 10 mm.Ua loiloi ʻia ka hana antimicrobial ma ke ana ʻana i ka nui o ka ʻāpana inhibitory.
ʻO ka maikaʻi o ka FRO ma CA-induced sebum production a me DHT-pili i nā androgen surges i loiloi ʻia me ka hoʻohana ʻana i ka Oil Red staining a me ka nānā ʻana o Western blot, kēlā me kēia.Ua hoʻāʻo ʻia ʻo FRO no kona hiki ke hoʻokaʻawale i nā hopena o nā ʻano oxygen reactive (ROS), nona ke kuleana no ka hyperpigmentation e pili ana i ka acne a me nā ʻōpala post-surgical, me ka hoʻohana ʻana i ka probe 2′,7′-dichlorofluorescein diacetate (DCF-DA).kumu.
Ua hōʻike ʻia nā hopena o ka hoʻokolohua disk diffusion i ka 20 μL o FRO i hoʻopaʻa maikaʻi i ka ulu ʻana o CA a hoʻopuka i kahi ʻāpana inhibition ʻike ʻia o 13 mm ma ke ʻano o 100 mg/mL.Hoʻopau nui ʻo FRO i ka hoʻonui ʻana i ka huna ʻana o ka sebum i hoʻokumu ʻia e SA, no laila e hoʻolohi a hoʻohuli paha i ke ʻano o ka haki.
Ua ʻike ʻia ʻo FRO he waiwai i nā pūhui phenolic me ka gallic acid, kaempferol, quercetin a me fisetin.Huina phenolic hui (TPC) awelika 118.2 mg gallic acid equivalents (GAE) no ka gram FRO.
Ua hōʻemi nui ʻo FRO i ka ʻāʻī o ka cellular i hoʻokumu ʻia e SA-induced ROS a me ka hoʻokuʻu cytokine.ʻO ka hoʻemi lōʻihi o ka hana ROS hiki ke hōʻemi i ka hyperpigmentation a me ka scarring.
ʻOiai ke loaʻa nei nā lāʻau lapaʻau dermatological no ka ʻeʻe, he nui ke kumukūʻai a hiki ke loaʻa i nā hopena ʻaoʻao makemake ʻole.
Hōʻike nā hopena i loaʻa iā FRO nā waiwai antibacterial e kūʻē i ka CA (bacteria kumu o ka ʻeʻe), no laila e hōʻike ana he ʻano kūlohelohe ʻo FRO, ʻaʻohe mea ʻawaʻawa a maikaʻi hoʻi i nā lāʻau lapaʻau kuʻuna.Hoʻemi pū ʻo FRO i ka hana sebum a me ka hōʻike ʻana i ka hormone in vitro, e hōʻike ana i kona pono i ka mālama ʻana a me ka pale ʻana i ka ʻāʻī ʻana.
Ua hōʻike ʻia nā hoʻokolohua lapaʻau FRO ma mua ua ʻike ka poʻe e hoʻohana ana i ka toner a me ka lotion holomua o FRO i nā hoʻomaikaʻi koʻikoʻi i ka elasticity o ka ʻili a me nā pae maʻamau i hoʻohālikelike ʻia i ka pūʻulu hoʻomalu ma hope o ʻeono pule wale nō.ʻOiai ʻaʻole i loiloi kēia haʻawina i ka ʻekene ma lalo o nā kūlana in vitro i hoʻomalu ʻia, kākoʻo nā hopena o kēia manawa i kā lākou ʻike.
Hoʻohui pū ʻia, kākoʻo kēia mau hopena i ka hoʻohana ʻana o FRO i ka wā e hiki mai ana i nā lāʻau lapaʻau, me ka mālama ʻana i ka haki a me ka hoʻomaikaʻi ʻana i ke olakino ʻili holoʻokoʻa.
Ua hoʻoponopono ʻia kēia ʻatikala ma Iune 9, 2023 e hoʻololi i ke kiʻi nui me kahi kiʻi kūpono.
Kau ʻia ma: Nūhou ʻEpekema Lapaʻau |Nūhou ʻImi Lapaʻau |Nuhou ma'i |Nūhou lāʻau lapaʻau
Tags: ʻāneʻe, ʻōpio, androgens, anti-inflammatory, cell, chromatography, cytokines, dihydrotestosterone, effectiveness, fermentation, genetics, ulu kumu, lauoho, hormones, hyperpigmentation, in vitro, mumū, insulin, phototherapy, chromatography wai, oxygen, proliferation , quercetin , retinoids, ʻili, ʻili ʻili, ʻili ʻili, Western blot
He mea kākau ʻepekema ʻo Hugo Francisco de Souza ma Bangalore, Karnataka, India.ʻO kāna mau pono hoʻonaʻauao aia ma nā kahua o ka biogeography, evolutionary biology a me herpetology.Ke hana nei ʻo ia i kāna dissertation doctoral.mai ka Center for Environmental Sciences ma ka Indian Institute of Science, kahi e aʻo ai i ke kumu, ka hāʻawi ʻana a me ka speciation o nā nahesa wetland.Ua hāʻawi ʻia ʻo Hugo i kahi DST-INSPIRE Fellowship no kāna noiʻi kauka a me kahi Medal gula mai ke Kulanui ʻo Pondicherry no kāna mau hana hoʻonaʻauao i ka wā o kāna aʻo ʻana.Ua paʻi ʻia kāna noiʻi ʻana i loko o nā puke moʻolelo i loiloi ʻia e nā hoa me ka PLOS Neglected Tropical Diseases and Systems Biology.Ke hana ʻole ʻo ia a kākau ʻole, hoʻokani ʻo Hugo i ka nui o nā anime a me nā comics, kākau a haku mele ma ke kīkā bass, ʻoki i nā ala ma ka MTB, pāʻani i nā pāʻani wikiō (makemake ʻo ia i ka huaʻōlelo "pāʻani") .ʻenehana.
ʻO Francisco de Souza, Hugo.(Iulai 9, 2023).Hāʻawi kahi hui kūikawā o nā mea kanu i nā pono anti-acne ikaika.Nūhou – Lapaʻau.Ua kiʻi ʻia i ka lā 11 o Kepakemapa, 2023, mai https://www.news-medical.net/news/20230709/Unique-plant-extract-mixture-has-pot-anti-acne-effects.aspx.
ʻO Francisco de Souza, Hugo."He hui kū hoʻokahi o nā mea kanu me nā waiwai anti-acne ikaika."Nūhou – Lapaʻau.Kepakemapa 11, 2023 .
ʻO Francisco de Souza, Hugo."He hui kū hoʻokahi o nā mea kanu me nā waiwai anti-acne ikaika."Nūhou – Lapaʻau.https://www.news-medical.net/news/20230709/Unique-plant-extract-mixture-has-pot-anti-acne-effects.aspx.(Loaʻa iā Kepakemapa 11, 2023).
ʻO Francisco de Souza, Hugo.2023. He hui kū hoʻokahi o nā mea kanu me nā waiwai anti-acne ikaika.News Medical, i loaʻa iā Kepakemapa 11, 2023, https://www.news-medical.net/news/20230709/Unique-plant-extract-mixture-has-pot-anti-acne-effects.aspx.
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