Hoʻohana mākou i nā kuki e hoʻomaikaʻi i kou ʻike. Ma ka hoʻomau ʻana e nānā i kēia pūnaewele, ʻae ʻoe i kā mākou hoʻohana ʻana i nā kuki. ʻIke hou aku.
Ma ke kaomi ʻana iā "ʻAe i nā mea āpau", ʻae ʻoe i ka mālama ʻana i nā kuki ma kāu hāmeʻa e hoʻomaikaʻi i ka hoʻokele pūnaewele, kālailai i ka hoʻohana ʻana i ka pūnaewele, a kākoʻo i kā mākou hāʻawi ʻana i nā ʻike ʻepekema manuahi a wehe ʻia. ʻIke hou aku.
Ma kahi noiʻi i paʻi ʻia ma ka puke pai Pharmaceutics, ua hoʻoholo nā kānaka noiʻi i ka pono antimicrobial o kahi ʻano lāʻau i kapa ʻia ʻo FRO e kūʻē i ka pathogenesis acne.
Ua hōʻike ʻia ka loiloi antimicrobial a me ka loiloi in vitro he hopena antibacterial a me anti-inflammatory koʻikoʻi ko FRO e kūʻē iā Dermatobacillus Acnes (CA), kahi bacteria e hoʻoulu ai i ka acne. Hōʻike kēia mau hopena i kona hoʻohana palekana a kūlohelohe i ka mālama ʻana i ka acne, e kākoʻo ana i ka hoʻohana ʻana i nā koho ʻē aʻe ʻaʻohe ʻawaʻawa a me ke kumukūʻai kūpono i nā lāʻau lapaʻau acne o kēia manawa.
Haʻawina: Ka pono o FRO i ka pathogenesis o ka acne vulgaris. Kiʻi kiʻi: Steve Jungs/Shutterstock.com
ʻO ka acne vulgaris, i ʻike nui ʻia ʻo pimples, he maʻi ʻili maʻamau i hoʻokumu ʻia e nā follicle lauoho i paʻa me ka sebum a me nā ʻili make. Hoʻopilikia ka acne ma mua o 80 pakeneka o nā ʻōpio a, ʻoiai ʻaʻole ia he make, hiki ke hoʻoulu i ka pilikia noʻonoʻo a, i nā hihia koʻikoʻi, ka pigmentation ʻili mau loa a me ka ʻeha.
Loaʻa ka ʻākea mai ka pilina o nā kumu genetic a me ke kaiapuni, i hana pinepine ʻia e nā loli hormonal e hele pū me ka wā ʻōpio i ka wā ʻōpio. Hoʻonui kēia mau kaulike ʻole hormonal i ka hana sebum a hoʻonui i ka hana insulin growth factor 1 (IGF-1) a me ka hana dihydrotestosterone (DHT).
ʻO ka hoʻonui ʻia ʻana o ka sebum secretion ka pae mua i ka ulu ʻana o ka acne, ʻoiai ʻo nā follicle lauoho i piha i ka sebum he nui nā microorganism e like me SA. He mea kūlohelohe ka SA o ka ʻili; akā naʻe, ʻo ka hoʻonui ʻia ʻana o kona phylotype IA1 ke kumu o ka mumū a me ka pigmentation o nā follicle lauoho me nā papules i ʻike ʻia ma waho.
Aia nā ʻano lāʻau hoʻonani like ʻole no ka ʻākena, e like me nā retinoids a me nā mea hana microbial topical, i hoʻohana ʻia me nā peels kemika, ka laser/light therapy, a me nā mea hana hormonal. Eia nō naʻe, he pipiʻi iki kēia mau lāʻau a pili pū me nā hopena ʻino.
Ua noiʻi nā haʻawina mua i nā mea kanu lāʻau ma ke ʻano he koho kūlohelohe kūpono i kēia mau lāʻau lapaʻau. Ma ke ʻano he koho ʻē aʻe, ua aʻo ʻia nā mea kanu Rhus vulgaris (RV). Eia nō naʻe, ua kaupalena ʻia kona hoʻohana ʻana e ka urushiol, kahi ʻāpana allergenic koʻikoʻi o kēia lāʻau.
He ʻano hana lāʻau lapaʻau ka FRO e loaʻa ana nā ʻāpana i hoʻoulu ʻia o RV (FRV) a me ka mangosteen Kepanī (OJ) ma ka lakio 1:1. Ua hoʻāʻo ʻia ka pono o ke ʻano hana me ka hoʻohana ʻana i nā hoʻāʻo in vitro a me nā waiwai antimicrobial.
Ua wehewehe mua ʻia ka hui ʻana o ka FRO me ka hoʻohana ʻana i ka chromatography wai hana kiʻekiʻe (HPLC) e hoʻokaʻawale, ʻike a helu i kona mau ʻāpana. Ua kālailai hou ʻia ka hui ʻana no ka ʻike phenolic holoʻokoʻa (TPC) e ʻike i nā hui i loaʻa nā waiwai antimicrobial.
ʻO ka hoʻāʻo antimicrobial mua in vitro ma ka loiloi ʻana i ka ʻike diffusion disc. ʻO ka mea mua, ua hoʻoulu like ʻia ʻo CA (phylotype IA1) ma kahi pā agar kahi i kau ʻia ai kahi disk pepa kānana 10 mm ke anawaena FRO-impregnated. Ua loiloi ʻia ka hana antimicrobial ma ke ana ʻana i ka nui o ka ʻāpana inhibitory.
Ua loiloi ʻia ka pono o FRO ma ka hana ʻana o ka sebum i hoʻokomo ʻia e CA a me nā piʻi ʻana o ka androgen e pili ana iā DHT me ka hoʻohana ʻana i ka ʻaila ʻulaʻula a me ka nānā ʻana o Western blot. Ma hope mai, ua hoʻāʻo ʻia ʻo FRO no kona hiki ke hoʻopau i nā hopena o nā ʻano oxygen reactive (ROS), nona ke kuleana no ka hyperpigmentation e pili ana i ka ʻāne a me nā ʻeha ma hope o ke ʻoki ʻana, me ka hoʻohana ʻana i kahi probe 2′,7′-dichlorofluorescein diacetate (DCF-DA).
Ua hōʻike ʻia nā hopena o ka hoʻokolohua hoʻolaha disk ua kāohi pono ʻo 20 μL o FRO i ka ulu ʻana o CA a ua hana i kahi ʻāpana kāohi o 13 mm ma kahi nui o 100 mg/mL. Hoʻopau nui ʻo FRO i ka hoʻonui ʻia o ka sebum secretion i hoʻokumu ʻia e SA, no laila e hoʻolohi a hoʻohuli paha i ka hanana o ka acne.
Ua ʻike ʻia he waiwai nui ka FRO i nā hui phenolic e komo pū ana me ka waikawa gallic, kaempferol, quercetin a me ka fisetin. ʻO ka awelika o ka hui phenolic (TPC) he 118.2 mg gallic acid equivalents (GAE) no kēlā me kēia gram FRO.
Ua hōʻemi nui ʻo FRO i ka mumū o ke kelepona i hoʻokumu ʻia e ka ROS i hoʻokomo ʻia e SA a me ka hoʻokuʻu ʻana o ka cytokine. ʻO ka hōʻemi lōʻihi ʻana i ka hana ROS e hōʻemi paha i ka hyperpigmentation a me ka scarring.
ʻOiai aia nā lāʻau lapaʻau dermatological no ka ʻākena, he nui ke kumukūʻai a hiki ke loaʻa nā hopena ʻaoʻao i makemake ʻole ʻia.
Hōʻike nā hopena he mau waiwai antibacterial ko FRO e kūʻē i ka CA (bacteria e hoʻoulu ai i ka acne), no laila e hōʻike ana he ʻano kūlohelohe, ʻaʻohe ʻawaʻawa a kūpono hoʻi ke kumukūʻai o FRO i nā lāʻau lapaʻau acne kuʻuna. Hoʻemi pū ʻo FRO i ka hana sebum a me ka hōʻike ʻana o ka hormone in vitro, e hōʻike ana i kona pono i ka mālama ʻana a me ka pale ʻana i ka hoʻāla ʻana o ka acne.
Ua hōʻike ʻia nā hoʻokolohua lapaʻau FRO ma mua ua ʻike ka poʻe e hoʻohana ana i ka toner a me ka lotion holomua o FRO i nā hoʻomaikaʻi koʻikoʻi i ka elasticity o ka ʻili a me nā pae makū i hoʻohālikelike ʻia me ka hui kaohi ma hope o ʻeono pule wale nō. ʻOiai ʻaʻole i loiloi kēia haʻawina i ka ʻākena ma lalo o nā kūlana in vitro i kāohi ʻia, kākoʻo nā hopena o kēia manawa i kā lākou mau ʻike.
I ka hui pū ʻia ʻana, kākoʻo kēia mau hopena i ka hoʻohana ʻana o FRO i ka wā e hiki mai ana i nā lāʻau hoʻonani, me ka mālama ʻana i ka ʻeha a me ka hoʻomaikaʻi ʻana i ke olakino ʻili holoʻokoʻa.
Ua hoʻoponopono ʻia kēia ʻatikala ma Iune 9, 2023 e pani i ke kiʻi nui me kahi kiʻi kūpono.
Ua kau ʻia ma: Nūhou ʻEpekema Lapaʻau | Nūhou Noiʻi Lapaʻau | Nūhou Maʻi | Nūhou Lāʻau Lapaʻau
Nā lepili: ʻāneʻane, ʻōpio, androgens, anti-inflammatory, nā pūnaewele, chromatography, cytokines, dihydrotestosterone, ka pono, fermentation, genetics, nā mea ulu, lauoho, hormones, hyperpigmentation, in vitro, mumū, insulin, phototherapy, chromatography wai, oxygen, proliferation, quercetin, retinoids, ʻili, nā pūnaewele ʻili, pigmentation ʻili, Western blot
He mea kākau ʻepekema ʻo Hugo Francisco de Souza ma Bangalore, Karnataka, India. Aia kona mau hoihoi hoʻonaʻauao ma nā kahua o ka biogeography, evolutionary biology a me ka herpetology. Ke hana nei ʻo ia i kāna dissertation doctoral. mai ke Kikowaena no nā ʻEpekema Kaiapuni ma ka Indian Institute of Science, kahi āna e aʻo ai i ke kumu, ka hoʻolaha ʻana a me ka speciation o nā nahesa wetland. Ua hāʻawi ʻia ʻo Hugo i kahi DST-INSPIRE Fellowship no kāna noiʻi doctoral a me kahi Medal Gula mai ke Kulanui ʻo Pondicherry no kāna mau hoʻokō hoʻonaʻauao i kāna mau haʻawina Master. Ua paʻi ʻia kāna noiʻi ma nā puke pai i loiloi ʻia e nā hoa e like me PLOS Neglected Tropical Diseases and Systems Biology. Ke hana ʻole ʻo ia a kākau, hoʻopau nui ʻo Hugo i nā anime a me nā comics, kākau a haku mele ma ka guitar bass, ʻokiʻoki i nā mele ma ka MTB, pāʻani i nā pāʻani wikiō (makemake ʻo ia i ka huaʻōlelo "pāʻani"), a i ʻole tinker me nā mea āpau. nā ʻenehana.
ʻO Francisco de Souza, ʻo Hugo. (Iulai 9, 2023). ʻO kahi hui kūikawā o nā mea kanu e hāʻawi i nā pono anti-acne ikaika. Nūhou - Lapaʻau. Ua kiʻi ʻia ma Kepakemapa 11, 2023, mai https://www.news-medical.net/news/20230709/Unique-plant-extract-mixture-has-pot-anti-acne-effects.aspx.
ʻO Francisco de Souza, ʻo Hugo. "He hui kūikawā o nā mea kanu me nā waiwai anti-acne ikaika." Nūhou - Lapaʻau. Kepakemapa 11, 2023.
ʻO Francisco de Souza, ʻo Hugo. "He hui kūikawā o nā mea kanu me nā waiwai anti-acne ikaika." Nūhou - Lapaʻau. https://www.news-medical.net/news/20230709/Unique-plant-extract-mixture-has-pot-anti-acne-effects.aspx. (Loaʻa ʻia Kepakemapa 11, 2023).
ʻO Francisco de Souza, ʻo Hugo. 2023. He hui kūikawā o nā mea kanu me nā waiwai anti-acne ikaika. Nūhou Lapaʻau, i komo ʻia ma Kepakemapa 11, 2023, https://www.news-medical.net/news/20230709/Unique-plant-extract-mixture-has-pot-anti-acne-effects.aspx.
ʻAʻole pili nā kiʻi i hoʻohana ʻia ma kēia "hōʻuluʻulu manaʻo" i kēia haʻawina a he kuhihewa loa ia i ka hōʻike ʻana ua pili ka haʻawina i ka hoʻāʻo ʻana ma luna o kānaka. Pono e wehe koke ʻia.
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Hāʻawi ʻo News-Medical.Net i nā lawelawe ʻike lapaʻau e pili ana i kēia mau ʻōlelo a me nā kūlana. E ʻoluʻolu e hoʻomaopopo ʻia ua manaʻo ʻia ka ʻike lapaʻau ma kēia pūnaewele e kākoʻo, a ʻaʻole e pani, i ka pilina ma waena o ka mea maʻi a me ke kauka a me nā ʻōlelo aʻoaʻo lapaʻau hiki iā lākou ke hāʻawi.