Hoʻohana mākou i nā kuki e hoʻomaikaʻi i kou ʻike. Ma ka hoʻomau ʻana i ka nānā ʻana i kēia pūnaewele, ʻae ʻoe i kā mākou hoʻohana ʻana i nā kuki. ʻIke hou aku.
Ma ke kaomi ʻana i ka "Allow All", ʻae ʻoe i ka mālama ʻana i nā kuki ma kāu hāmeʻa e hoʻomaikaʻi i ka hoʻokele pūnaewele, ka nānā ʻana i ka hoʻohana ʻana i ka pūnaewele, a kākoʻo i kā mākou hāʻawi ʻana i ka ʻike ʻepekema manuahi. ʻIke hou aku.
I loko o kahi noiʻi hou i paʻi ʻia ma ka puke pai Pharmaceutics, ua hoʻoholo nā mea noiʻi i ka hopena antimicrobial o kahi lāʻau lapaʻau i kapa ʻia ʻo FRO e kūʻē i ka pathogenesis acne.
Ua hōʻike ʻia ka loiloi antimicrobial a me ka nānā ʻana in vitro he nui nā hopena antibacterial a anti-inflammatory iā FRO e kūʻē iā Dermatobacillus Acnes (CA), he hua bacteria e hoʻoulu ai i ka haki. Hōʻike kēia mau hopena i kona hoʻohana pono ʻana a me ka hoʻohana maoli ʻana i ka hoʻomaʻamaʻa ʻana i ka ʻeʻe, e kākoʻo ana i ka hoʻohana ʻana i nā mea ʻawaʻawa ʻole a me nā kumu kūʻai i nā lāʻau lapaʻau o kēia manawa.
Haʻawina: ʻO ka maikaʻi o FRO i ka pathogenesis o ka acne vulgaris. Kiʻi kiʻi: Steve Jungs/Shutterstock.com
ʻO Acne vulgaris, i kapa ʻia ʻo nā pimples, he maʻi ʻili maʻamau i hoʻokumu ʻia e nā follicles lauoho paʻa me ka sebum a me nā ʻili ʻili make. ʻOi aku ka maʻi o ka Acne ma mua o 80 pakeneka o ka poʻe ʻōpio a, ʻoiai ʻaʻole ia he mea make, hiki ke hoʻopilikia i ka noʻonoʻo a, i nā hihia koʻikoʻi, ka pigmentation mau a me ka ʻili ʻili.
Loaʻa ka ʻāʻī mai kahi pilina o nā ʻano genetic a me ke kaiapuni, i hana pinepine ʻia e nā loli hormonal e hele pū me ka wā ʻōpio. Hoʻonui kēia mau ʻano hormonal i ka hana sebum a hoʻonui i ka insulin growth factor 1 (IGF-1) a me ka hana dihydrotestosterone (DHT).
ʻO ka hoʻonui ʻia ʻana o ka sebum huna i manaʻo ʻia ʻo ka pae mua o ka hoʻomohala ʻana i ka haki, no ka mea, ʻo nā follicles lauoho i hoʻopiha ʻia me ka sebum ka nui o nā microorganisms e like me SA. ʻO ka SA kahi mea commensal maoli o ka ʻili; akā naʻe, hoʻonui ʻia ka hoʻonui ʻana o kāna phylotype IA1 ke kumu i ka mumū a me ka pigmentation o nā follicles lauoho me nā papules ʻike ʻia i waho.
Aia nā lāʻau lapaʻau like ʻole no ka haki, e like me nā retinoids a me nā mea hana microbial topical, i hoʻohana pū ʻia me nā peels kemika, laser/light therapy, a me nā mea hana hormonal. Eia nō naʻe, ʻano pipiʻi kēia mau lāʻau lapaʻau a pili pū me nā hopena ʻino.
Ua ʻimi nā haʻawina mua i nā mea kanu lāʻau ma ke ʻano he kumu kūʻai kūʻai maoli no kēia mau lāʻau lapaʻau. Ma ke ʻano he ʻokoʻa, ua aʻo ʻia nā ʻāpana Rhus vulgaris (RV). Eia naʻe, ua kaupalena ʻia kona hoʻohana ʻana e ka urushiol, kahi mea allergenic nui o kēia kumulāʻau.
ʻO ka FRO kahi mea kanu lāʻau i loaʻa nā ʻāpana fermented o RV (FRV) a me Japanese mangosteen (OJ) ma kahi ratio 1:1. Ua hoʻāʻo ʻia ka maikaʻi o ke ʻano me ka hoʻohana ʻana i nā in vitro assays a me nā waiwai antimicrobial.
Ua ʻike mua ʻia ka hui ʻana o FRO me ka hoʻohana ʻana i ka chromatography wai hana kiʻekiʻe (HPLC) e hoʻokaʻawale, ʻike a helu i kona mau ʻāpana. Hoʻopili hou ʻia ka hui ʻana no ka huina phenolic content (TPC) e ʻike ai i nā pūhui i loaʻa nā waiwai antimicrobial.
Hoʻomaka mua in vitro antimicrobial assay ma ka nānā ʻana i ka ʻike diffusion disc. ʻO ka mua, ua hoʻoulu like ʻia ʻo CA (phylotype IA1) ma luna o kahi pā agaru kahi i kau ʻia ai kahi disk pepa kānana FRO-impregnated 10 mm. Ua loiloi ʻia ka hana antimicrobial ma ke ana ʻana i ka nui o ka ʻāpana inhibitory.
ʻO ka maikaʻi o ka FRO ma CA-induced sebum production a me DHT-pili i nā androgen surges i loiloi ʻia me ka hoʻohana ʻana i ka Oil Red staining a me ka nānā ʻana o Western blot, kēlā me kēia. Ua hoʻāʻo ʻia ʻo FRO no kona hiki ke hoʻokaʻawale i nā hopena o nā ʻano oxygen reactive (ROS), nona ke kuleana no ka hyperpigmentation e pili ana i ka acne a me nā ʻōpala post-surgical, me ka hoʻohana ʻana i ka probe 2′,7′-dichlorofluorescein diacetate (DCF-DA). kumu.
Ua hōʻike ʻia nā hopena o ka hoʻokolohua disk diffusion i ka 20 μL o FRO i hoʻopaʻa maikaʻi i ka ulu ʻana o CA a hoʻopuka i kahi ʻāpana inhibition ʻike ʻia o 13 mm ma ke ʻano o 100 mg/mL. Kāohi nui ʻo FRO i ka piʻi ʻana o ka huna ʻana o ka sebum i hoʻokumu ʻia e SA, no laila e hoʻolohi a hoʻohuli paha i ka hiki ʻana o ka haki.
Ua ʻike ʻia ʻo FRO he waiwai i nā pūhui phenolic me ka gallic acid, kaempferol, quercetin a me fisetin. Huina phenolic hui (TPC) awelika 118.2 mg gallic acid equivalents (GAE) no ka gram FRO.
Ua hōʻemi nui ʻo FRO i ka ʻāʻī o ka cellular i hoʻokumu ʻia e SA-induced ROS a me ka hoʻokuʻu cytokine. ʻO ka hoʻemi lōʻihi o ka hana ROS hiki ke hōʻemi i ka hyperpigmentation a me ka scarring.
ʻOiai ke loaʻa nei nā lāʻau lapaʻau dermatological no ka ʻeʻe, he nui ke kumukūʻai a hiki ke loaʻa i nā hopena ʻaoʻao makemake ʻole.
Hōʻike nā hualoaʻa he mau waiwai antibacterial ʻo FRO e kūʻē iā CA (acne-causing bacteria), no laila e hōʻike ana he ʻano kūlohelohe ʻo FRO, ʻaʻohe mea ʻawaʻawa a me ke kumu kūʻai i nā lāʻau lapaʻau kuʻuna. Hoʻemi pū ʻo FRO i ka hana sebum a me ka hōʻike ʻana i ka hormone i loko o ka vitro, e hōʻike ana i kona pono i ka mālama ʻana a me ka pale ʻana i ka ʻāʻī ʻana.
Ua hōʻike ʻia nā hoʻokolohua lapaʻau FRO ma mua ua ʻike ka poʻe e hoʻohana ana i ka toner a me ka lotion kiʻekiʻe o FRO i nā hoʻomaikaʻi koʻikoʻi i ka elasticity o ka ʻili a me nā pae wai i hoʻohālikelike ʻia me ka hui hoʻomalu ma hope o ʻeono pule wale nō. ʻOiai ʻaʻole i loiloi kēia haʻawina i ka ʻekene ma lalo o nā kūlana in vitro i hoʻomalu ʻia, kākoʻo nā hopena o kēia manawa i kā lākou ʻike.
Hoʻohui pū ʻia, kākoʻo kēia mau hopena i ka hoʻohana ʻana o FRO i ka wā e hiki mai ana i nā lāʻau lapaʻau, me ka mālama ʻana i ka haki a me ka hoʻomaikaʻi ʻana i ke olakino ʻili holoʻokoʻa.
Ua hoʻoponopono ʻia kēia ʻatikala ma Iune 9, 2023 e hoʻololi i ke kiʻi nui me kahi kiʻi kūpono.
Kau ʻia ma: Nūhou ʻepekema Lapaʻau | Nūhou ʻImi Lapaʻau | Nuhou ma'i | Nūhou lāʻau lapaʻau
Tags: ʻāneʻe, ʻōpio, androgens, anti-inflammatory, cell, chromatography, cytokines, dihydrotestosterone, effectiveness, fermentation, genetics, ulu kumu, lauoho, hormones, hyperpigmentation, in vitro, mumū, insulin, phototherapy, chromatography wai, oxygen, proliferation , quercetin , retinoids, ʻili, ʻili ʻili, ʻili ʻili, Western blot
He mea kākau ʻepekema ʻo Hugo Francisco de Souza ma Bangalore, Karnataka, India. ʻO kāna mau pono hoʻonaʻauao aia ma nā kahua o ka biogeography, evolutionary biology a me herpetology. Ke hana nei ʻo ia i kāna dissertation doctoral. mai ka Center for Environmental Sciences ma ka Indian Institute of Science, kahi e aʻo ai i ke kumu, ka hāʻawi ʻana a me ka speciation o nā nahesa wetland. Ua hāʻawi ʻia ʻo Hugo i kahi DST-INSPIRE Fellowship no kāna noiʻi kauka a me ka Medal gula mai ke Kulanui ʻo Pondicherry no kāna mau hana hoʻonaʻauao i ka wā o kāna aʻo ʻana. Ua paʻi ʻia kāna noiʻi ʻana i loko o nā puke moʻolelo i loiloi ʻia e nā hoa me ka PLOS Neglected Tropical Diseases and Systems Biology. Ke ʻaʻole ʻo ia e hana a kākau, hoʻokani ʻo Hugo i ka nui o nā anime a me nā comics, kākau a haku mele ma ke kīkā bass, ʻoki i nā ala ma ka MTB, pāʻani i nā pāʻani wikiō (makemake ʻo ia i ka huaʻōlelo "pāʻani") . ʻenehana.
Francisco de Souza, Hugo. (Iulai 9, 2023). Hāʻawi kahi hui kūikawā o nā mea kanu i nā pono anti-acne ikaika. Nūhou – Lapaʻau. Ua kiʻi ʻia i ka lā 11 o Kepakemapa, 2023, mai https://www.news-medical.net/news/20230709/Unique-plant-extract-mixture-has-pot-anti-acne-effects.aspx.
Francisco de Souza, Hugo. "He hui kū hoʻokahi o nā mea kanu me nā waiwai anti-acne ikaika." Nūhou – Lapaʻau. Kepakemapa 11, 2023 .
Francisco de Souza, Hugo. "He hui kū hoʻokahi o nā mea kanu me nā waiwai anti-acne ikaika." Nūhou – Lapaʻau. https://www.news-medical.net/news/20230709/Unique-plant-extract-mixture-has-pot-anti-acne-effects.aspx. (Loaʻa iā Kepakemapa 11, 2023).
Francisco de Souza, Hugo. 2023. He hui kū hoʻokahi o nā mea kanu me nā waiwai anti-acne ikaika. Nūhou Lapaʻau, loaʻa iā Kepakemapa 11, 2023, https://www.news-medical.net/news/20230709/Unique-plant-extract-mixture-has-pot-anti-acne-effects.aspx.
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